Begin main content

Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety

Last updated: September 9, 2016
Project Number: RA0864-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Reference List
Result type: Report

Question

  1. What is the clinical effectiveness and safety of different individual doses of acetaminophen for patients with pain or fever?
  2. What is the clinical effectiveness and safety of doses in excess of the recommended daily maximum dose (4 g) for patients with pain or fever?
  3. What is the safety of chronic use of acetaminophen?

Key Message

Thirty-three systematic reviews and meta-analyses were identified regarding the effectiveness and safety of acetaminophen.