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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis B: A Review of Diagnostic Accuracy, Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Published on: May 4, 2016
Project Number: RC0776-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical effectiveness of acoustic radiation force impulse imaging compared with liver biopsy for detecting and grading liver fibrosis in patients with hepatitis B?
  2. What is the diagnostic accuracy of acoustic radiation force impulse imaging compared with liver biopsy for detecting and grading liver fibrosis in patients with hepatitis B?
  3. What is the cost-effectiveness of acoustic radiation force impulse imaging compared with liver biopsy for detecting and grading liver fibrosis in patients with hepatitis B?
  4. What are the evidence-based guidelines regarding use of acoustic radiation force impulse imaging for detecting and grading liver fibrosis in patients with hepatitis B?

Key Message

Eleven studies were identified regarding the diagnostic accuracy of acoustic radiation force impulse imaging compared with liver biopsy for detecting and grading liver fibrosis with hepatitis B. There were mixed results on the use of ARFI to evaluate liver fibrosis in patients with hepatitis B. One study was identified on the cost-effectiveness of ARFI. ARFI was dominated by less costly and more effective options among hepatitis B e antigen-positive patients (high levels of the virus and greater infectiousness); however, ARFI was extendedly dominated in hepatitis B e antigen-negative patients (low to zero level of the virus and less infectious). No literature was found regarding the clinical effectiveness or evidence-based guidelines.

Tags

elasticity imaging techniques, liver diseases, imaging, liver, ultrasound, ARFI; Acoustic radiation force impulse; Acoustic radiation force impulses; Virtual touch quantification; VTq; cirrhosis; cirrhotic; hepatic; Hep B