Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Refractory or High-Risk Patients


( Last Updated : May 31, 2022)
Project Line:
Health Technology Review
Project Sub Line:
Rapid Review
Project Number:
RC1430-000

Details


Question

  1. What is the clinical effectiveness of aprepitant for the prevention of PONV in patients with a history of PONV refractory to conventional antiemetic prophylaxis?
  2. What is the clinical effectiveness of aprepitant for the prevention of PONV in patients with the potential for life-threatening post-operative medical complications due to emesis?
  3. What is the cost-effectiveness of aprepitant for the prevention of PONV in patients with a history of PONV refractory to conventional antiemetic prophylaxis?
  4. What is the cost-effectiveness of aprepitant for the prevention of PONV in patients with the potential for life-threatening post-operative medical complications due to emesis?
  5. What are the evidence-based guidelines regarding the use of aprepitant for the prevention of PONV in patients with a history of PONV refractory to conventional antiemetic prophylaxis?
  6. What are the evidence-based guidelines regarding the use of aprepitant for the prevention of PONV in patients with the potential for life-threatening post-operative medical complications due to emesis?

Key Message

No studies were found that evaluated the clinical effectiveness of aprepitant for the prevention of post-operative nausea and vomiting in patients with a history of post-operative nausea and vomiting refractory to conventional antiemetic prophylaxis that met the criteria for this review.

In patients with the potential for life-threatening post-operative medical complications due to emesis, limited evidence of variable quality was identified for the clinical effectiveness of aprepitant. The studies varied by population, the combination of interventions and comparators and the outcomes measured, and the findings were mixed.

No studies were found that evaluated the cost-effectiveness of aprepitant for the prevention of post-operative nausea and vomiting in patients with a history of post-operative nausea and vomiting refractory to conventional antiemetic prophylaxis that met the criteria for this review.

No studies were found that evaluated the cost-effectiveness of aprepitant for the prevention of post-operative nausea and vomiting in patients with the potential for life-threatening post-operative medical complications due to emesis that met the criteria for this review.

No evidence-based guidelines were found regarding the use of aprepitant for the prevention of post-operative nausea and vomiting in patients with a history of post-operative nausea and vomiting refractory to conventional antiemetic prophylaxis that met the criteria for this review.

No evidence-based guidelines were found regarding the use of aprepitant for the prevention of post-operative nausea and vomiting in patients with the potential for life-threatening post-operative medical complications due to emesis that met the criteria for this review.