Aripiprazole for Borderline Personality Disorder: A Review of the Clinical Effectiveness


Project Status:
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:


  1. What is the clinical effectiveness of aripiprazole for the treatment of borderline personality disorder?

Key Message

The findings observed in two relatively small RCTs indicated that aripiprazole appears to be a safe and effective agent in the long term treatment of patients with borderline personality disorder. Similar clinical effectiveness and safety profiles were reported comparing aripiprazole with olanzapine in the treatment of BPD. However, due to the methodological limitations of the study design, whether the findings reported in the included RCTs could be generalized to Canadian routine clinical practice settings is uncertain and should be interpreted with caution.