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Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines

Last updated: December 11, 2018
Project Number: RB1285-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of plasma or prothrombin complex concentrate transfusions prior to surgical procedures in individuals with an elevated international normalized ratio?
  2. What is the evidence for the safety of undergoing surgical procedures for individuals with an elevated international normalized ratio?
  3. What are the evidence-based guidelines regarding pre-surgical transfusion considerations for individuals with clotting or coagulation concerns?

Key Message

One randomized controlled trial and seven non-randomized studies were identified regarding pre-surgery transfusion in individuals with an elevated international normalized ratio. In addition, three evidence-based guidelines were identified regarding pre-surgery transfusion considerations for individuals with clotting or coagulation concerns.