Browse by Drug Category

• Opiates and Opioids
• Stimulants
• Tranquilizers and Sedatives

Opiates and Opioids

• Buprenorphine hydrochloride (Probuphine) for the treatment of opioid drug dependence (Active Drug Review Submission) 
• Tapentadol Hydrochloride (Nucynta) for Pain Management (Active Drug Review Submission)
• Fentanyl buccal (Fentora) for Breakthrough Cancer Pain (Adults)  (Drug Review Recommendation, Feb. 2017)
• Fentanyl Citrate (Onsolis) for Breakthrough Cancer Pain (Adults) (Drug Review Recommendation, Feb. 2012)
• Oxycodone HCI / Naloxone HCI (Targin) for Moderate to Severe Pain and Relief of Opioid-Induced Constipation (Drug Review Recommendation, Jan. 2012)
• Fentanyl Citrate (Abstral) for Breakthrough Cancer Pain (Drug Review Recommendation, Dec. 2011)
• Buprenorphine Transdermal Patch (BuTrans) for Persistent Pain (Moderate Intensity) (Drug Review Recommendation, Sept. 2011)
• Tapentadol (Nucynta CR) for Severe to Moderately Severe Pain (Drug Review Recommendation, Sept. 2011)
• Hydromorphone Hydrochloride (Jurnista) for Chronic Pain (Moderate to Severe) (Drug Review Recommendation, May 2010)
• Opioids for Chronic Pain (Overview of Themes and Resources, Apr. 2013)
• Policies to Reduce Harms from the Concomitant Use of Opioids and Central Nervous System Depressant Drugs (Environmental Scan, Apr. 2018) 
• Injectable Extended-Release Naltrexone to Treat Opioid Use Disorder  (Issues in Emerging Health Technologies, Aug. 2017)
• Buprenorphine Implant for the Treatment of Opioid Use Disorder  (Issues in Emerging Health Technologies, Mar. 2017)
• Buprenorphine/Naloxone Versus Methadone for the Treatment of Opioid Dependence: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness and Guidelines (Peer-Reviewed Summary With Critical Appraisal, Sept. 2016)
• Buprenorphine Formulations for the Treatment of Opioid Use Disorders: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness and Guidelines  (Summary With Critical Appraisal, July 2017)
• Naltrexone for Opioid Use Disorders: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines  (Summary With Critical Appraisal, July 2017) 
• Intranasal and Intramuscular Naloxone for Opioid Overdose in the Pre-Hospital Setting: A Review of Comparative Clinical and Cost-Effectiveness, and Guidelines  (Summary With Critical Appraisal, Mar. 2017)
• Buprenorphine for Chronic Pain: A Review of the Clinical Effectiveness  (Summary With Critical Appraisal, Jan. 2017)
• Crushed Buprenorphine or Buprenorphine-Naloxone for Opioid Dependency: A Review of the Clinical Effectiveness and Guidelines (Summary With Critical Appraisal, July 2016)
• Rapid and Ultra-Rapid Detoxification in Adults With Opioid Addiction: A Review of Clinical- and Cost-Effectiveness, Safety, and Guidelines (Summary With Critical Appraisal, Jan. 2016)
• Tamper-Resistant Formulations of Opioids (Environmental Scan)
• Administration of Naloxone in a Home or Community Setting: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines (Summary With Critical Appraisal, June 2014)
• Stepwise Approach for the Prescription of Opiates for Non-Cancer Pain: A Review of Clinical Evidence and Guidelines (Summary With Critical Appraisal, May 2014)
• Antiemetics for Adults Experiencing Opioid-Induced Nausea: A Review of Clinical and Cost-Effectiveness, Benefits and Harms, and Guidelines (Summary With Critical Appraisal, Apr. 2014)
• Suboxone Versus Methadone for the Detoxification of Patients Addicted to Prescription Opioids: A Review of Comparative Clinical Effectiveness, Safety, and Guidelines (Summary With Critical Appraisal, Feb. 2014)
• Suboxone Versus Methadone for the Treatment of Opioid Dependence: A Review of the Clinical and Cost-effectiveness (Summary With Critical Appraisal, Nov. 2013)
• Pentazocine versus Short-acting Opioids for Chronic or Acute Pain: A Review of the Clinical Effectiveness (Summary With Critical Appraisal, May 2013)
• Treatment for Opioid Dependence: A Review of Guidelines (Summary With Critical Appraisal, Sept. 2012)
• Opioid Trial Periods for Management of Chronic Non-Cancer Pain: A Review of Clinical Evidence, Guidelines and Recommendations (Summary With Critical Appraisal, June 2012)
• Watchful Dosing of Morphine or Morphine Equivalent Dosing in the Treatment of Chronic Non-Cancer Pain: A Review of the Clinical Evidence (Summary With Critical Appraisal, June 2012)
• Codeine and Acetaminophen for Pain Relief: A Review of the Clinical Efficacy and Safety (Summary With Critical Appraisal, Apr. 2012)
• Opioid Management Practices for the Prevention of Drug Diversion and Misuse: A Review of the Clinical Evidence and Guidelines (Summary With Critical Appraisal, Apr. 2012)
• Prevention Strategies for Substance Misuse Harm Reduction A Review of Clinical Evidence (Summary With Critical Appraisal, Jan. 2012)
• Combination Benzodiazepine-Opioid Use: A Review of the Evidence on Safety (Summary With Critical Appraisal, Sept. 2011)
• The Use of OxyNEO and OxyContin in Adults: A Review of the Evidence on Safety (Summary With Critical Appraisal, Sept. 2011)
• Tramadol Compared with Opioids for Pain: A Review of Addiction Potential (Summary With Critical Appraisal, Jan. 2010)
• Metadol Liquid, Methadose, and Compounded Methadone in Patients Using Opioid Agonist Therapy: Comparative Clinical Effectiveness and Guidelines (Summary of Abstracts, Apr. 2018) 
• Intranasal Sufentanil for Acute Pain: Clinical Effectiveness and Guidelines (Summary of Abstracts, Dec. 2017)
• Strategies for the Reduction or Discontinuation of Opioids: Guidelines  (Summary of Abstracts, Apr. 2017)
• Sustained Release Oral Morphine, Injectable Hydromorphone, and Prescription Diacetylmorphine for Opioid Use Disorder: Clinical and Cost-Effectiveness, and Guidelines  (Summary of Abstracts, Apr. 2017)
• Intranasal and Intramuscular Naloxone for Opioid Overdose in the Pre-Hospital Setting: Comparative Clinical Effectiveness and Cost-Effectiveness (Summary of Abstracts, Sept. 2016)
• Moderate Procedural Sedation in Adult Patients: Guidelines (Summary of Abstracts, Sept. 2016)
• Medications for the Management of Post-Surgical Pain in Pediatrics: Guidelines (Summary of Abstracts, July 2016)
• Pain Management for Women, Aboriginal Peoples, or the Elderly: Guidelines (Summary of Abstracts, Mar. 2016)
• Capnography and/or Oximetry Monitoring of Patients Using Patient-Controlled Intravenous Opioids: Clinical and Cost-Effectiveness, Safety, and Guidelines (Summary of Abstracts, May 2013)
• Codeine Compared with Other Opioids for Pain Relief in Pediatric Patients: Comparative Clinical Effectiveness, Safety, and Guidelines (Summary of Abstracts, Feb. 2013)
• Buprenorphine Formulations for the Treatment of Opioid Use Disorders: Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines (Reference List, Apr. 2018) 
• The Use of Transdermal Buprenorphine Patches in Aiding in Opioid Withdrawal: Clinical Effectiveness and Guidelines  (Reference List, June 2017)
• Combination Benzodiazepine-Opioid Use: Clinical Evidence and Guidelines (Reference List, Mar. 2015)
• Evaluation of Opioid Use for Patients with Chronic Non-Cancer Pain: Clinical Evidence (Reference List, June 2012)
• Mucosal Atomization Devices for the Administration of Pain Medications: Clinical Effectiveness, Safety, and Guidelines (Reference List, Jan. 2012)
• Long-acting Opioids for Chronic Pain: Comparative Efficacy and Safety (Reference List, Oct. 2011)
• Opioids in Combination with Local Anesthetics for Pain Control: Clinical Effectiveness and Guidelines (Reference List, Feb. 2010)

Stimulants

• Guanfacine hydrochloride (Intuniv XR) for Attention-Deficit/Hyperactivity Disorder (Drug Review Recommendation, Sept. 2014)
• Pharmacologic-based Strategies for Smoking Cessation (Health Technology Assessment)
• Drugs for Smoking Cessation (Knowledge Mobilization tools)
• Pharmacological and Non-pharmacological Therapies for Adults with Attention-Deficit/Hyperactivity Disorder: Systematic Review and Meta-analysis of Clinical Evidence (Systematic Review and Meta-Analysis, Sept. 2011)
• Smoking Cessation Interventions for Patients with Severe Mental Illnesses: A Review of Clinical Effectiveness and Guidelines  (Summary With Critical Appraisal, Aug. 2017)
• High-Dose Stimulants for Attention-Deficit/Hyperactivity Disorder: A Review of the Clinical Effectiveness, Safety, and Guidelines (Summary With Critical Appraisal, Mar. 2016)
• Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness (Summary With Critical Appraisal, Mar. 2016)
• Pharmacologic Management of Patients With ADHD: Review of Guidelines (Summary With Critical Appraisal, Mar. 2016)
• Combination Therapy for Attention-Deficit/Hyperactivity Disorder: A Review of the Clinical Effectiveness (Summary With Critical Appraisal, Feb. 2016)
• Abuse and Misuse Potential of Drugs for Attention-Deficit/Hyperactivity Disorder: A Review of the Clinical Evidence (Summary With Critical Appraisal, Aug. 2013)
• Tricyclic Antidepressants, Clonidine, Venlafaxine, and Modafinil for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: A Review of the Clinical Evidence (Summary With Critical Appraisal, Mar. 2013)
• Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety (Summary With Critical Appraisal, July 2012)
• Pharmacologic Smoking Cessation Interventions for Patients with Cardiovascular Conditions: A Review of the Safety and Guidelines (Summary With Critical Appraisal, May 2012)
• Nicotine Replacement Therapy for Smoking Cessation or Reduction: A Review of the Clinical Evidence (Summary With Critical Appraisal, Jan. 2012)
• Bupropion for Depressive Illness: Abuse Potential and Clinical Practice Guidelines (Summary With Critical Appraisal, Oct. 2010)
• Use of Bupropion in Patients with Depression and the Associated Risk of Seizures: Safety (Summary With Critical Appraisal, Apr. 2010)
• The Assessment and Treatment of Adult Inmates with Attention Deficit Hyperactivity Disorder: Clinical Effectiveness and Guidelines  (Summary of Abstracts, June 2017)
• Smoking Cessation Interventions for Patients with Severe Mental Illnesses: Clinical Effectiveness and Guidelines (Reference List, Aug. 2016)
• High Dose Stimulants for Attention-Deficit/Hyperactivity Disorder: Clinical Effectiveness, Safety, and Guidelines (Reference List, Jan. 2015)

Tranquilizers and Sedatives

• Current Practice Analysis: Interventions for Insomnia Disorder  (Optimal Use Project, June 2017) 
• Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines (Peer-Reviewed Summary with Critical Appraisal, Jan. 2011)
• Short-Acting Agents and Dissociative Agents for Conscious Sedation During Endoscopy Procedures: Systematic Review of Clinical and Cost-Effectiveness and Guidelines (Peer-Reviewed Summary with Critical Appraisal, Sept. 2010)
• Treatment of Older Adults with Insomnia, Agitation, or Delirium with Benzodiazepines: Clinical Effectiveness and Guidelines (Summary With Critical Appraisal, Jan. 2016)
• Ketamine for Treatment-Resistant Depression or PTSD in Various Settings: A Review of Clinical Effectiveness, Safety, and Guidelines  (Summary With Critical Appraisal, Mar. 2017)
• Use of Antipsychotics and/or Benzodiazepines as Rapid Tranquilization in In-Patients of Mental Facilities and Emergency Departments: A Review of the Clinical Effectiveness and Guidelines  (Summary With Critical Appraisal, Oct. 2015)
• Sedation and Anesthesia Options for Diagnostic Procedures: A Review of Clinical Effectiveness and Guidelines (Summary With Critical Appraisal, May 2015)
• Dexmedetomidine for Sedation in the ICU or PICU: A Review of Cost-Effectiveness and Guidelines (Summary With Critical Appraisal, Dec. 2014)
• Short- and Long-Term Use of Benzodiazepines in Patients with Generalized Anxiety Disorder: A Review of Guidelines (Summary With Critical Appraisal, July 2014)
• Dexmedetomidine for Sedation of Patients in the ICU or PICU: Review of Clinical Effectiveness and Safety (Summary With Critical Appraisal, Jan. 2014)
• Combination Benzodiazepine-Opioid Use: A Review of the Evidence on Safety (Summary With Critical Appraisal, Sept. 2011)
• High Dose and Watchful Dosing of Benzodiazepines: A Review of the Safety and Guidelines (Summary With Critical Appraisal, Nov. 2012)
• Propofol for Conscious Sedation During Endoscopies: Clinical Effectiveness, Cost-Effectiveness, and Guidelines (Summary of Abstracts, Nov. 2017)
• Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines  (Summary of Abstracts, Mar. 2017)
• Sleep Medications for the Treatment or Prevention of Delirium: Clinical Effectiveness and Guidelines  (Summary of Abstracts, Dec. 2016)
• Benzodiazepines for the Treatment of Post-Traumatic Stress Disorder: A Review of the Clinical Effectiveness and Guidelines (Summary With Critical Appraisal, Dec. 2009)
• Moderate Procedural Sedation in Adult Patients: Guidelines (Summary of Abstracts, Sept. 2016)
• Treatment of Older Adults with Insomnia, Agitation, or Delirium With Benzodiazepines: Clinical Effectiveness and Guidelines (Summary of Abstracts, Apr. 2015)
• The Use of Chemical Restraints in the Pre-hospital Setting: Guidelines (Summary of Abstracts, Mar. 2015)
• Short-acting Benzodiazepines versus other Strategies for the Management of Agitation in Older Patients: Clinical Effectiveness and Guidelines (Summary of Abstracts, June 2010)
• Discontinuation Strategies for Patients With Long-Term Z-drug Use: Clinical Evidence and Guidelines (Reference List, Jan. 2015)
• Sleep Medications for Adults Diagnosed with Insomnia: Clinical Evidence and Harms (Reference List, Apr. 2013)
• Sleep Medications: Clinical Effectiveness, Safety, Cost-Effectiveness, and Guidelines (Reference List, July 2010)
• Chemical and Environmental Restraints in Acute and Long-Term Care: Guidelines (Reference List, Feb. 2010)