CADTH | Evidence Driven
CADTH | Evidence Driven

Combination Benzodiazepine-Opioid Use: Clinical Evidence and Guidelines

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Project Line:
Reference List
Project Sub Line:
Reference List
Project Number:
RA0744-000

Question


  1. What is the clinical evidence on the risk of serious adverse events associated with combination benzodiazepine-opioid use for adults with chronic non-cancer pain?

  2. What is the comparative efficacy and safety of combination benzodiazepine-opioid use compared with opioids alone for chronic non-cancer pain with or without comorbidity?

  3. What is the comparative clinical evidence on different benzodiazepine-opioid treatment strategies?

  4. What are the evidence-based guidelines regarding combination benzodiazepine-opioid use?


Key Message

One systematic review, two non-randomized studies, and three evidence-based guidelines were identified regarding combination benzodiazepine-opioid use.


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Combination Benzodiazepine-Opioid Use: Clinical Evidence and Guidelines Rapid Response March 26, 2015 View PDF

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Last Updated : March 26, 2015