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Combination Benzodiazepine-Opioid Use: Clinical Evidence and Guidelines

Last updated: March 26, 2015
Project Number: RA0744-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Reference List
Result type: Report


  1. What is the clinical evidence on the risk of serious adverse events associated with combination benzodiazepine-opioid use for adults with chronic non-cancer pain?
  2. What is the comparative efficacy and safety of combination benzodiazepine-opioid use compared with opioids alone for chronic non-cancer pain with or without comorbidity?
  3. What is the comparative clinical evidence on different benzodiazepine-opioid treatment strategies?
  4. What are the evidence-based guidelines regarding combination benzodiazepine-opioid use?

Key Message

One systematic review, two non-randomized studies, and three evidence-based guidelines were identified regarding combination benzodiazepine-opioid use.