Dexamethasone Intravitreal Implant for the Treatment of Macular Edema Following Retinal Detachment Surgery


( Last Updated : May 20, 2022)
Project Line:
Health Technology Review
Project Sub Line:
Rapid Review
Project Number:
RC1428-000

Details


Question

  1. What is the clinical effectiveness of dexamethasone intravitreal implant versus no treatment or placebo for the treatment of macular edema following retinal detachment surgery?
  2. What is the clinical effectiveness of dexamethasone intravitreal implant versus alternative interventions for the treatment of macular edema following retinal detachment surgery?
  3. What is the cost-effectiveness of dexamethasone intravitreal implant versus no treatment or placebo for the treatment of macular edema following retinal detachment surgery?
  4. What is the cost-effectiveness of dexamethasone intravitreal implant versus alternative interventions for the treatment of macular edema following retinal detachment surgery?
  5. What are the evidence-based guidelines regarding dexamethasone intravitreal implant for the treatment of macular edema following retinal detachment surgery?

Key Message

Evidence from 1 systematic review and 2 observational studies suggests that dexamethasone intravitreal implant is associated with improvement in macular edema secondary to retinal detachment surgery.

The evidence primarily came from low- to moderate-quality studies.

It is challenging to draw definitive conclusions about the effectiveness of this intervention because of the paucity of data, the lack of controlled clinical studies, and the retrospective nature of the current literature.

No evidence was identified on the cost-effectiveness of dexamethasone intravitreal implant for the treatment of macular edema secondary to retinal detachment surgery.