Dicyclomine for Gastrointestinal Conditions: A Review of the Clinical Effectiveness, Safety, and Guidelines
( Last Updated : December 3, 2015)
Health Technology Review
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Summary with Critical Appraisal
What is the clinical effectiveness and safety of dicyclomine for gastrointestinal tract conditions involving smooth muscle spasm?
What are the evidence-based guidelines for the use of dicyclomine for gastrointestinal conditions?
Recent evidence on the use of dicyclomine for GI tract conditions involving smooth muscle spasm is lacking. A limited amount of evidence published before 2005, identified in selected guidelines, has shown that dicyclomine is superior to placebo in improving IBS global assessment, and leads to more adverse events. Guidelines based on this evidence have recommended dicyclomine as a pharmacological treatment of IBS, as well as other antispasmodics such as mebeverine and alverine citrate. The recommendation was considered by the authors to be definitive based on low-quality evidence with uncertain trade-offs between benefits and harms.