Evidence Related to Oncology
Here you'll find an up-to-date collection of CADTH’s oncology-related products.
The bundle includes reports and other resources on a variety of topics related to the diagnosis and treatment of cancer. CADTH has reviewed the evidence on various cancer treatments, screening and diagnostic technologies, and ways to manage symptoms associated with cancer and its treatment.
You can also view cancer drug recommendations on the CADTH drug decision program section of our website. The CADTH drug decision program uses information gained through its reviews of clinical evidence, cost-effectiveness, and patient perspectives to make recommendations to Canada's provinces and territories (except Quebec) that they can use to guide their drug funding decision-making.
We’ve selected the following materials to get you started:
- Pediatric Glioma Learning Project (Health Technology Assessment, October 27, 2022)
- Transanal Total Mesorectal Excision for Adult Patients with Rectal Cancer (Rapid Review, November 7, 2022)
- Azacitidine for Acute Myeloid Leukemia (Health Technology Review, October 24, 2022)
- Antiviral Prophylaxis With Tenofovir for Patients With History of Hepatitis B Receiving Oncology Drug Treatment (Rapid Review, September 9, 2022)
- An Overview of Comprehensive Genomic Profiling Technologies to Inform Cancer Care (Emerging Health Technologies, August 10, 2022)
- Low-Dose Ipilimumab in Combination With Nivolumab or Pembrolizumab for the Treatment of Advanced Melanoma (Rapid Review, August 2, 2022)
In this Bundle
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Switching from Herceptin or other Trastuzumab Biosimilars to Biosimilar Ogviri
(Reference List, February 4, 2019)
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Raltitrexed in patients with dihydropyrimidine dehydrogenase (DPD) deficiency
(Reference List, November 7, 2022)
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Azacitidine for Acute myeloid leukemia
Short on time? Read the In Brief.
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Everolimus for Functional Neuroendocrine Tumours of Gastrointestinal or Lung Origin
(Reference List, April 6, 2022)
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Encorafenib for Small Bowel Adenocarcinoma or Appendiceal Adenocarcinoma With BRAF V600E Mutation
(Reference List, August 30, 2021)
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Natriuretic Peptide testing for Monitoring of Oncology Therapy: Clinical Utility, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, August 6, 2019)
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Extended Dosing (12 Cycles) of Adjuvant Temozolomide in Adults with Newly Diagnosed High Grade Gliomas: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, February 26, 2018)
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Digital Pathology Using Primary Case Sign-out
(Reference List, October 14, 2021)
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Digital pathology technology for histopathological diagnosis
(Summary of Abstracts, March 17, 2021)
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PET Imaging with Prostate-Specific Membrane Antigen for Prostate Cancer: Clinical Utility
(Summary of Abstracts, November 26, 2020)
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Digital Radiography versus Computed Radiography: Comparative Diagnostic Accuracy, Clinical Utility, Safety, and Guidelines
(Reference List, October 13, 2020)
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Experiences and Perspectives on Endoscopic Ultrasound for the Diagnosis and Treatment of Pancreatic Diseases: A Rapid Qualitative Review
(Summary with Critical Appraisal, June 30, 2020)
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Pleuroscopy for the Diagnosis of Cancer in Patients with Pleural Effusion: A Review of the Diagnostic Accuracy, Safety, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, April 27, 2020)
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Magnetic Localization System for Sentinel Lymph Node Biopsy: A Review of the Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, March 2, 2020)
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Circulating Tumour DNA Testing for the Identification of Genetic Mutations: Diagnostic Test Accuracy and Clinical Utility
(Reference List, February 24, 2020)
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Artificial Intelligence for Classification of Lung Nodules: A Review of Clinical Utility, Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, February 18, 2020)
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Biopsy for Adults with Suspected Skin Cancer: A Rapid Qualitative Review
(Summary with Critical Appraisal, November 21, 2019)
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Chlorhexidine Gluconate for Skin Preparation During Stereotactic Core Biopsy of the Breast: Clinical Effectiveness and Guidelines
(Summary of Abstracts, February 8, 2019)
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Low-Dose Ipilimumab in Combination With Nivolumab or Pembrolizumab for the Treatment of Advanced Melanoma
(Rapid Review, August 2, 2022)
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Axicabtagene Ciloleucel and Tisagenlecleucel for Diffuse Large B-cell Lymphoma
(Summary of Abstracts, January 26, 2022)
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Pembrolizumab for Microsatellite Instability-High or Mismatch Repair Deficient Small Bowel Adenocarcinoma or Appendiceal Adenocarcinoma
(Rapid Review, October 22, 2021)
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Dosing and Timing of Immuno-Oncology Drugs
Short on Time? Read the In Brief.
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Axicabtagene Ciloleucel for Adults With Relapsed or Refractory Large B-cell Lymphoma
(Optimal Use, August 15, 2019)
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Cancer Immunotherapy After Adjuvant Immunotherapy: Clinical Effectiveness and Guidelines
(Reference List, August 1, 2019)
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Tisagenlecleucel (Kymriah) for Pediatric Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma
Short on time? Read the In Brief
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Pediatric Glioma Learning Project
(Report, October 27, 2022)
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An Overview of Comprehensive Genomic Profiling Technologies to Inform Cancer Care
(Emerging Health Technologies, August 10, 2022)
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Virtual Oncology Visits
(Summary of Abstracts, July 21, 2022)
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Infliximab for Graft versus Host Disease
(Summary of Abstracts, July 6, 2022)
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Private IV Infusion Clinics in Canada
(Environmental Scan, June 24, 2022)
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Pharmacological Thromboprophylaxis in Patients With Cancer
(Rapid Review, November 9, 2021)
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Reference Filgrastim (Neupogen) for Pediatric Patients With Cancer
(Summary of Abstracts, September 8, 2021)
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Cryotherapy for Prostate Cancer: Clinical Effectiveness and Guidelines
(Reference List, October 3, 2019)
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Combination Therapy for the Treatment of Central Nervous System Malignancies: Clinical Effectiveness and Guidelines
(Summary of Abstracts, February 8, 2019)
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Combination Therapy for the Treatment of Adults with Any Stage Breast Cancer: Clinical Effectiveness and Guidelines
(Summary of Abstracts, February 5, 2019)
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Low Dose Naltrexone for the Treatment of Any Cancer Type: Clinical Effectiveness and Guidelines
(Summary of Abstracts, January 8, 2019)
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Alternating Electric Fields ("Tumour- Treating Fields") for the Treatment of Glioblastoma
(Emerging Health Technologies, January 16, 2018)
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Prescriptive Nutritional Guidance for Prevention of Cancer: Guidelines
(Summary of Abstracts, February 26, 2020)
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Whole Breast Radiotherapy as Part of Breast Conserving Therapy
(Summary of Abstracts, July 20, 2022)
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Stereotactic Ablative Radiotherapy for the Treatment of Oligometastatic Cancer
(Report, June 21, 2022)
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Whole Brain Radiation Therapy for Patients With Limited Brain Metastases
(Summary of Abstracts, June 20, 2022)
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Radioiodine Resensitization for Radioiodine Refractory Metastatic Differentiated Thyroid Cancer
(Rapid Review, April 15, 2022)
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Implementation of Stereotactic Ablative Radiotherapy for the Treatment of Oligometastatic Cancer in Canada
(Environmental Scan, July 14, 2021)
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Yttrium 90 Microspheres for Advanced, Recurrent, or Inoperable Hepatocellular Carcinoma: A Review of Clinical and Cost Effectiveness
(Rapid Review with Expert Input, March 1, 2021)
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Brachytherapy Administration for Cervical and Vaginal Cancer: Safety and Guidelines
(Summary of Abstracts, March 23, 2020)
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Magnetic Resonance-Guided Radiotherapy: MR-Simulation and MR-Linac
(Emerging Health Technologies, January 16, 2020)
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Magnetic Resonance Imaging-Guided Radiotherapy Delivery Systems for Cancer Treatment: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, March 25, 2019)
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Hydrogel Spacers for Patients with Prostate Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, February 22, 2019)
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Stereotactic Body Radiotherapy for Oligometastatic Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, February 6, 2019)
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Magnetic Resonance Imaging Simulators for Simulation and Treatment for Patients Requiring Radiation Therapy: A Review of the Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, January 16, 2019)
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Breast Cancer Screening
(Reference List, August 3, 2022)
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Emerging Multi-Cancer Early Detection Technologies
(Health Technology Update, April 22, 2022)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A 2021 Update
(Summary of Abstracts, September 7, 2021)
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HPV Testing for Primary Cervical Cancer Screening
(Summary of Abstracts, August 20, 2021)
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Routine Pelvic Examination for the Detection of Malignant or Benign Gynecological Conditions
(Reference List, July 13, 2021)
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Breast and Cervical Cancer Screening Recommendations for Transgender or Non-Binary Individuals
(Summary of Abstracts, March 23, 2021)
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Colorectal and Breast Cancer Screening for Survivors of Childhood, Adolescent, or Young Adult Cancers
(Summary of Abstracts, March 16, 2021)
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Claus Risk Assessment Model for Patients Eligible for Routine Breast Cancer Screening
(Summary of Abstracts, February 18, 2021)
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Lung Cancer Screening: Clinical Utility and Guidelines
(Reference List, October 13, 2020)
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Triage Tools and Management Algorithms for Colorectal Cancer Screening: Guidelines
(Summary of Abstracts, September 3, 2020)
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An Overview of Liquid Biopsy for Screening and Early Detection of Cancer
(Report, November 14, 2019)
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Artificial Intelligence for Classification of Lung Nodules: Clinical Utility, Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, November 14, 2019)
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Risk Calculators for Prostate Cancer: Clinical Utility and Guidelines
(Reference List, October 31, 2019)
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Digital Breast Tomosynthesis for the Screening and Diagnosis of Breast Cancer: A Review of the Diagnostic Accuracy, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, October 28, 2019)
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Anal Cancer Screening in High Risk Populations: Clinical Effectiveness, Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, September 20, 2019)
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HPV Testing for Primary Cervical Cancer Screening
Short on time? Read the In Brief.
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Digital Tomosynthesis for the Screening and Diagnosis of Breast Cancer: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, June 11, 2019)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A Review of Diagnostic Test Accuracy and Clinical Evidence – An Update
Short on time? Read the In Brief .
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Gene Expression Profiling Tests for Breast Cancer: A Rapid Qualitative Review
(Summary with Critical Appraisal, April 18, 2019)
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Urinary Dipstick Testing for Bladder Cancer Screening: Diagnostic Accuracy, Clinical Effectiveness and Guidelines
(Summary of Abstracts, April 1, 2019)
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Transanal Total Mesorectal Excision for Adult Patients with Rectal Cancer
(Rapid Review, November 7, 2022)
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Surveillance Colonoscopy Following Surgery for Colon Cancer
(Summary of Abstracts, July 7, 2022)
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5-Aminolevulinic Acid Hydrochloride–Guided Surgical Resection of High-Grade Gliomas
(Reference List, July 13, 2021)
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Blue Light and White Light Cystoscopy for Transurethral Resection of Bladder Tumour in People Living With Non-Muscle Invasive Bladder Cancer
(Reference List, April 26, 2021)
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Transanal Total Mesorectal Excision for Adult Patients with Rectal Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, May 4, 2020)
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Robotic Surgical Systems for Use in Gynecologic Oncology or Urologic Surgery: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, April 13, 2020)
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Magnetic seed localization for soft tissue lesions in breast patients: Clinical effectiveness, cost-effectiveness, and guidelines
(Summary with Critical Appraisal, May 23, 2019)
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Rural Breast Cancer Surgery Programs: A Rapid Qualitative Review
(Summary with Critical Appraisal, May 3, 2019)
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Sentinel Lymph Node Biopsy for the Management of Breast Cancer: A Review of Guidelines
(Summary with Critical Appraisal, April 24, 2019)
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Intraoperative Mammography for Breast Cancer Surgery: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, April 22, 2019)
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Preoperative Seed Placement for Breast Cancer Surgery: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, April 1, 2019)
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Mohs Surgery for Patients with Skin Cancer: A Review of Guidelines
(Summary with Critical Appraisal, March 20, 2019)
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Palonosetron for Patients Undergoing High or Moderate Emetogenic Chemotherapy
(Summary with Critical Appraisal, July 21, 2021)
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Lidocaine Infusions for Palliative Care Patients with Cancer Pain
(Reference List, April 26, 2021)
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Vandetanib for Medullary Thyroid Cancer
(Technology Review, July 13, 2022)
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Abiraterone Acetate for Metastatic Castrate Sensitive Prostate Cancer
(Peer-reviewed Summary with Critical Appraisal, June 2, 2021)
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Treatment Sequences of Androgen Receptor Targeted Agents for Patients with Prostate Cancer
(Summary with Critical Appraisal, March 17, 2021)
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PET Diagnostic Imaging with Prostate-Specific Membrane Antigen for Prostate Cancer: A Review of Clinical Utility, Cost-Effectiveness, Diagnostic Accuracy, and Guidelines
(Summary with Critical Appraisal, November 26, 2020)
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Trastuzumab Combination and Monotherapy for HER2 Advanced or Recurrent Uterine or Endometrial Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, November 26, 2020)
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Androgen Receptor Targeted Agents for Castration Resistant Prostate Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, June 6, 2019)
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Combination Agents for Multiple Myeloma: Comparative Clinical Effectiveness
(Summary of Abstracts, March 18, 2019)
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ALK Inhibitors for Non–Small Cell Lung Cancer
(Technology Review, February 20, 2019)
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Canadian Medical Imaging Inventory
(Tools, December 11, 2023)
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Evidence Highlights: HPV Testing for Primary Cervical Cancer Screening
Highlights from the CADTH Optimal Use project that assessed the clinical effectiveness, cost-effectiveness, patients’ perspectives and experiences, ethical considerations, and implementation issues associated with HPV testing for primary cervical cancer screening.
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Summary Tool: Evidence-Based Recommendations on Mohs Micrographic Surgery for the Treatment of Skin Cancer
A tool summarizing the findings of a CADTH review of the evidence-based guidelines on the use of Mohs micrographic surgery to treat skin cancer.
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Cervical cancer screening: Is it time for a new test?
Hospital News Article, June 2019
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Gene therapy is here: Now what?
Hospital News article, December 2018
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Searching for better glioblastoma treatment options and outcomes
Hospital News article, August 2018
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Consultation on Proposal to Integrate Key Functions of the Cancer Drug Implementation Advisory Committee into CADTH’s pan-Canadian Oncology Drug Review Process
(Webinar, March 4, 2019)
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Stereotactic ablative body radiotherapy: A paradigm shift – or even a potential cure – for oligometastatic cancer?
Hospital News article, May 2020
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Why Oncology Needs More Common Sense and Less Cheerleading
(Webinar, September 6, 2019)
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COVID-19 and Its Impact on Cancer Patients, Survivors, and Health Systems
(Webinar, February 17, 2022)
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An innovation in cancer treatment: Do we need proton beam therapy here?
Hospital News article, February 2018