Key Message
No relevant clinical studies were identified regarding the frequency of changing extension tubing on PICCs for patients in community settings. Two evidence-based guidelines were retrieved and suggested replacing administration sets for all vascular access devices (VADs), including PICCs, no more frequently than at 72-hour intervals if in continuous use. One of the guidelines suggested replacing VAD administration sets every 24 hours if in intermittent use. Both guidelines suggested more frequent replacing of VAD administration sets (e.g., every four to 24 hours) for infusates that contain lipid emulsions, blood, or blood products, or immediate replacing if contamination is suspected or if the integrity of the system has been compromised.