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Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Efficacy and Safety

Last updated: April 14, 2015
Project Number: RC0637-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical efficacy and safety of gabapentin compared with placebo for adults with neuropathic pain?
  2. What is the clinical efficacy and safety of gabapentin compared with placebo in a subset of adults with diabetic peripheral neuropathy?

Key Message

Overall there is a suggestion that there is greater reduction in neuropathic pain with gabapentin compared with placebo in adults with a variety of conditions including diabetic peripheral neuropathy. Generally, adverse events were numerically higher with gabapentin compared with placebo.