Question
- What is the clinical effectiveness of gabapentin for the treatment of HIV-associated neuropathic pain?
Key Message
There is limited evidence for the use of gabapentin for the treatment of HIV-associated neuropathy. One relevant RCT, included in a systematic review, and one non-randomized study were identified. The studies suggest that gabapentin may improve pain and related sleep disturbances caused by HIV-associated sensory neuropathy; however, due to the limitations of the evidence, the effectiveness of gabapentin for patients with HIV-associated neuropathy is inconclusive.