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Hydroxycobalamin for Cyanide Poisoning in the Pre-Hospital Setting: A Review of the Comparative Clinical Effectiveness and Safety

Last updated: June 26, 2012
Project Number: RC0365-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What is the comparative clinical effectiveness of hydroxycobalamin versus amyl nitrate or sodium thiosulfate for the treatment of cyanide poisoning resulting from smoke inhalation in the pre-hospital setting?
  2. What is the clinical evidence regarding the safety of hydroxycobalamin for the treatment of cyanide poisoning resulting from smoke inhalation?

Key Message

No evidence was found regarding the comparative clinical effectiveness and safety of hydroxocobalamin versus amyl nitrite, thiosulfate and sodium nitrite for pre-hospital treatment of smoke inhalation-associated cyanide poisoning.