Intranasal Corticosteroids for the Management of Chronic Rhinosinusitis or Nasal Polyposis in Cystic Fibrosis: A Review of Clinical Effectiveness

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Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC1083-000

Question

  1. What is the clinical effectiveness of intranasal corticosteroids for the management of chronic rhinosinusitis or nasal polyposis in patients with cystic fibrosis?

Key Message

One systematic review with one included trial reported that a topical steroid (betamethasone) was effective in reducing the size of nasal polyps for people with cystic fibrosis, without significant improvement in nasal symptoms. There was insufficient evidence to support or refute the use of intranasal corticosteroids for treatment of chronic rhinosinusitis or polyposis for those with cystic fibrosis.