Question
- What is the clinical effectiveness of IVIG for off-label uses?
Key Message
Results in some studies suggested that IVIG reduced all-cause mortality in patients with sepsis or septic shock, but the quality of evidence for both adults and neonates was considered low. Whereas the findings in other studies failed to demonstrate that IVIG had a statistically significant impact on these patient populations. There was insufficient evidence to assess the effectiveness of IVIG used to treat patients with Alzheimers disease, bone marrow or stem cell transplantation, epilepsy, or influenza.