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Lidocaine 2% with Epinephrine versus Lidocaine 1% with Epinephrine for Patients Requiring Local Anesthesia: Clinical Effectiveness and Guidelines

Last updated: May 3, 2019
Project Number: RA1030-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Reference List
Result type: Report

Question

  1. What is the comparative clinical effectiveness of lidocaine 2% with epinephrine versus lidocaine 1% with epinephrine for patients requiring local anesthesia?
  2. What are the evidence-based guidelines regarding the use of lidocaine (1% or 2%) with epinephrine for the use of patients requiring local anesthesia?

Key Message

Two randomized controlled trials were identified regarding the comparative clinical effectiveness of lidocaine 2% with epinephrine versus lidocaine 1% with epinephrine for patients requiring local anesthesia. In addition, no relevant evidence-based guidelines were identified.