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Linaclotide for Constipation: Clinical and Cost-Effectiveness

Last updated: June 21, 2016
Project Number: RA0852-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Reference List
Result type: Report

Question

  1. What is the clinical effectiveness of linaclotide for the treatment of patients with chronic idiopathic constipation?
  2. What is the clinical effectiveness of linaclotide for the treatment of patients with irritable bowel syndrome with constipation?
  3. What is the cost-effectiveness of linaclotide for the treatment of patients with chronic idiopathic constipation
  4. What is the cost-effectiveness of linaclotide for the treatment of patients with irritable bowel syndrome with constipation?

Key Message

Eight systematic reviews, three randomized controlled trials, six non-randomized studies, and three economic evaluations were identified regarding the clinical and cost-effectiveness of linaclotide for the treatment of patients with chronic idiopathic constipation or irritable bowel syndrome with constipation.