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Long-acting Opioids for Chronic Non-cancer Pain: A Review of the Clinical Efficacy and Safety

Published on: August 27, 2015
Project Number: RC0698-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What is the comparative efficacy and safety of long-acting opioids in adults with chronic non-cancer pain?

Key Message

One systematic review of long-term (>3 months) treatment and one extension study of an earlier randomized controlled trial comparing two opioids were identified. There is insufficient evidence assessing long-acting opioids, and insufficient evidence to discriminate between the four long-acting opioids in terms of efficacy and safety.


analgesics, anesthesia, chronic pain, delayed-action preparations, fentanyl, hydromorphone, morphine, opioids, oxycodone, pain, Opioid, morphines