Nasal Decolonization for the Prevention of Surgical Site Infections: Clinical Effectiveness, Cost-Effectiveness, and Guidelines


( Last Updated : March 9, 2020)
Project Status:
Completed
Project Line:
Reference List
Project Sub Line:
Reference List
Project Number:
RA1094-000

Details


Question


  1. What is the clinical effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections?

  2. What is the cost-effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections?

  3. What are the evidence-based guidelines regarding pre-operative interventions for the prevention of surgical site infections?


Key Message

One overview of reviews, five systematic reviews (three with meta-analyses), and four randomized controlled trials were identified regarding the clinical effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections. Additionally, one economic evaluation was identified regarding the cost-effectiveness of pre-operative nasal decolonization, with or without chlorhexidine gluconate washes or wipes, for the prevention of surgical site infections. Furthermore, eight evidence-based guidelines were identified regarding pre-operative interventions for the prevention of surgical site infections.​