New at CADTH — February 2019

News and Events

Nominations are now open for our Patient and Community Advisory Committee. CADTH is looking for 12 individuals who have experience engaging with the Canadian health care system. Apply here before February 24.

Registration is now open for the 2019 CADTH Symposium, being held in Edmonton, Alberta, from April 14 to 16, 2019.

Drug Reimbursement Recommendations

CADTH recently issued the following CADTH Canadian Drug Expert Committee (CDEC) drug reimbursement recommendations:

• lixisenatide and insulin glargine (Soliqua) for type 2 diabetes mellitus
• ertugliflozin (Steglatro) for type 2 diabetes mellitus
• ertugliflozin and metformin hydrochloride (Segluromet) for type 2 diabetes mellitus
• sucroferric oxyhydroxide (Velphoro) for hyperphosphatemia, end-stage renal disease.

CADTH Pan-Canadian Oncology Drug Review (pCODR)

CADTH recently issued the following pan-Canadian Oncology Drug Review (pCODR) Expert Review Committee (pERC) Drug Reimbursement Recommendations:

• osimertinib (Tagrisso) for the first-line treatment of patients with locally advanced or metastatic non–small cell lung cancer whose tumours have epidermal growth factor receptor mutations
• cabozantinib (Cabometyx) for the treatment of patients with advanced renal cell carcinoma who have received prior therapy
• bevacizumab (Mvasi) for first-line treatment of patients with metastatic carcinoma of the colon or rectum, in combination with fluoropyrimidine based chemotherapy; for treatment of patients with unresectable advanced, metastatic, or recurrent non-squamous non–small cell lung cancer, in combination with carboplatin/paclitaxel chemotherapy regimen.

CADTH Reports

CADTH recently completed the following reports:

Rapid Response Reports — Drug

• Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness — Reference List
• Topical Cantharidin/Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines — Reference List
• Injectable Hemin for Patients with Acute Porphyria: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines — Reference List
• Low Dose Naltrexone for the Treatment of Any Cancer Type: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Nonsteroidal Anti-Inflammatory Drugs and Acute Kidney Injury: Safety — Summary of Abstracts
• Nonsteroidal Anti-Inflammatory Drugs and Hypertension: Safety — Summary of Abstracts
• Atypical Injectable Antipsychotics for Schizophrenia or Bipolar Disorder: A Review of Clinical Effectiveness and Cost-Effectiveness — Summary with Critical Appraisal
• Emollient Treatments for Atopic Dermatitis: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• High Dose Influenza Vaccine for Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal

Rapid Response Reports — Medical Devices and Systems

• Lethal Means Counselling for Suicide Prevention: Clinical Effectiveness and Guidelines — Reference List
• Resiliency Interventions for Adverse Childhood Experiences in All Ages: Clinical Effectiveness and Guidelines — Reference List
• Adverse Childhood Experience Questionnaire for All Ages: Clinical Effectiveness — Reference List
• Additional Precautions for Methicillin-Resistant Staphylococcus Aureus, Vancomycin-Resistant Enterococci and/or Extended Spectrum Beta-Lactamase-Producing Organisms: Clinical Effectiveness and Guidelines — Reference List
• Decolonization for the Treatment of Methicillin-Resistant Staphylococcus Aureus: Clinical Effectiveness and Guidelines — Reference List
• Optical Topographical Imaging System: Clinical Effectiveness, Cost-Effectiveness, and Safety — Reference List
• Subcutaneous Butterfly Lines for Medication Administration: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Tongue and Lip Tie Cutting for Posterior Tongue Tie and Lip Tie: Clinical Effectiveness — Summary of Abstracts
• Dietary Priority Screening for Chronic Kidney Disease: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Portable Versus Fixed X-ray Equipment: Clinical and Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Weighted Blankets for Dementia Care in Long-Term Care: Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Mattresses or Overlays Used in Palliative End-of-Life Care: Clinical Evidence and Guidelines — Summary of Abstracts
• Antisepsis for Urinary Catheter Insertion: A Review of Clinical Effectiveness and Guidelines — Summary with Critical Appraisal
• Residential Treatment for Substance Use Disorder: A Review of Clinical Effectiveness — Summary with Critical Appraisal
• Interventions for Malnutrition in Seniors: A Review of Clinical Effectiveness — Summary with Critical Appraisal
• Meal Delivery Programs for Community Seniors: A Review of Clinical Effectiveness — Summary with Critical Appraisal
• Coated and Uncoated Central Venous Catheters: A Review of Comparative Clinical Effectiveness and Safety — Summary with Critical Appraisal
• Magnetic Resonance Imaging Simulators for Simulation and Treatment for Patients Requiring Radiation Therapy: A Review of the Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Clinical Decision Support Systems for Appropriate Medical Imaging: Clinical Evidence and Cost-Effectiveness — Summary with Critical Appraisal
• Cooling for Thermal Burns: Clinical Effectiveness and Guidelines — Summary with Critical Appraisal
• Chlorhexidine for Oral Care: A Review of Clinical Effectiveness and Guidelines — Summary with Critical Appraisal

Environmental Scans

• Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan

Tools

• Interventions for Insomnia Disorder
• Publicly Funded and Managed Naloxone Programs in Canada

Tell Us What You Think

We love hearing how our products and services are influencing health care policies, clinical practices, and patient outcomes. If you have a success story to share, please get in touch with your CADTH Liaison Officer.

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