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Non-Insulin Therapies versus Prandial Insulin for Adults with Type 2 Diabetes: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Last updated: April 24, 2019
Project Number: RB1329-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the comparative clinical effectiveness of non-insulin therapies versus prandial insulin for the treatment of adults with type 2 diabetes who are receiving basal insulin?
  2. What is the comparative cost-effectiveness of non-insulin therapies versus prandial insulin for the treatment of adults with type 2 diabetes who are receiving basal insulin?
  3. What are the evidence-based guidelines regarding the use non-insulin therapies for the treatment of adults with type 2 diabetes who are receiving basal insulin?

Key Message

Six systematic reviews (four with meta-analyses), five randomized controlled trials, five non-randomized studies, and nine economic evaluations were identified regarding non-insulin therapies versus prandial insulin for the treatment of adults with type 2 diabetes who are receiving basal insulin. In addition, three evidence-based guidelines were identified.