CADTH is committed to supporting Canada’s health care decision-makers through this challenging and uncertain time.
For evidence, tools, and resources related to COVID-19, visit our COVID-19 Evidence Portal.


Begin main content

Perioperative Use of NSAIDs: Safety and Guidelines

Last updated: April 5, 2018
Project Number: RB1205-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report


  1. What is the clinical evidence regarding the safety and harms of the perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs)?
  2. What are the evidence-based guidelines regarding the perioperative use of NSAIDs?

Key Message

Eight systematic reviews (six with meta-analyses), six randomized controlled trials, 21 non-randomized studies, and three evidence-based guidelines were identified regarding the perioperative use of NSAIDs.