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Point of Care Tests for Infectious Diseases: Review of Clinical and Cost-Effectiveness, and Guidelines

Published on: March 7, 2016
Project Number: RC0758-000
Product Line: Rapid Response
Research Type: Other Diagnostics
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the diagnostic accuracy of point of care tests (POCT) for HIV, hepatitis C, influenza, and Streptococcal infections compared with conventional testing in a laboratory?
  2. What is the clinical effectiveness of patient self-testing or pharmacist testing with POCT for HIV, hepatitis C, influenza, or Streptococcal infections compared with conventional testing in a laboratory?
  3. What is the cost-effectiveness of patient self-testing or pharmacist testing with POCT for HIV, hepatitis C, influenza, or Streptococcal infections compared with conventional testing in a laboratory?
  4. What are the evidence-based guidelines regarding patient self-testing or pharmacist testing with POCT for HIV, hepatitis C, influenza, or Streptococcal infections?

Key Message

Meta-analyses found that POC tests provide a reliable diagnostic strategy for hepatitis C virus or group A streptococcal pharyngitis infections, but performance may vary among different POC tests. Findings from one trial showed that POC testing can be a useful tool for diagnosis or triage (high specificity) for influenza A and B infection, but its low sensitivity suggests a negative POC tests needs confirmation using PCR assay. The costs for POC tests for hepatitis C infection or laboratory-based tests are similar. There was no evidence found on the clinical effectiveness of patient self-testing or pharmacist testing with POCT for HIV, hepatitis C, influenza, or Streptococcal infections compared with conventional testing in a laboratory. No evidence-based guidelines for their use were identified.

Tags

diagnostic tests, hiv, hepatitis c, pharmacies, point-of-care systems, streptococcal infections, streptococcus, Diagnostic, Flu, POCT, Reagent Kits, rapid diagnostic test, rapid test, strep