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Probiotics for Antibiotic-Associated Diarrhea and Clostridium difficile Infection: A Review of Guidelines

Last updated: September 6, 2018
Project Number: RC1013-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What are the evidence-based guidelines regarding the use of probiotics for the prevention, management, and treatment of antibiotic-associated diarrhea and C. difficile infection?

Key Message

One guideline recommended the use of probiotics for treatment of antibiotic associated diarrhea (varying strength of recommendation depending on the product).Four guidelines did not recommend the use of probiotics for prevention of C. difficile infection; and two of these guidelines also did not recommend use of probiotics for treatment of C. difficile infection. One guideline mentioned that probiotics may be considered for prevention and treatment of C. difficle (weak recommendation)