Prucalopride for Gastrointestinal Motility Disorders: A Review of Clinical Effectiveness

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Project Status:
Completed
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC0944-000

Question


  1. What is the clinical effectiveness of prucalopride for the treatment of gastrointestinal motility disorders (i.e., chronic constipation, ileus, refractory gastroparesis, intestinal pseudo-obstruction)?


Key Message

Findings from three SRs showed that prucalopride seems to be a beneficial pharmacotherapy in the treatment of chronic constipation, but with an increase in adverse event rates compared to placebo. Indirect comparison showed there was no significant difference in efficacy among prucalopride and other pharmacotherapies. Limited evidence from two RCTs found prucalopride is a safe and effective treatment to reduce the symptoms of post-operative ileus and chronic intestinal pseudo-obstruction. There was no evidence found on the comparative efficacy of prucalopride for refractory gastroparesis.