- What is the clinical effectiveness of regional chemotherapy for adults with metastatic breast cancer?
- What is the cost-effectiveness of regional chemotherapy for adults with metastatic breast cancer?
- What are the evidence-based guidelines associated with the use of regional chemotherapy for the treatment of adults with metastatic breast cancer?
Evidence of very limited quality from six non-randomized studies indicated that regional chemotherapy may provide benefit with regard to tumour response and survival; however, additional evidence from high quality, randomized controlled trials is required to better assess whether regional chemotherapy offers a benefit relative to conventional and other therapies. Studies showed that regional chemotherapy was minimally associated with toxicity.No evidence regarding cost-effectiveness or evidence-based guidelines describing regional chemotherapy for metastatic breast cancer was identified.