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Reports

We found 182 result(s)

Esketamine for Treatment-Resistant Depression

Last Updated: April 17, 2019
Result type: Reports
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Major depressive disorder (MDD) is a common, debilitating, and recurrent mental health disorder. Approximately 10% to 30% of patients with MDD will not reach complete clinical remission despite multiple antidepressant pharmacologic approaches — this subpopulation is described as having treatment-resistant depression (TRD). TRD is a more chall...

  • Project Number: EH0075-000

An Overview of Clinical Applications of 3-D Printing and Bioprinting

Last Updated: April 15, 2019
Result type: Reports
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In the 1980s, the first 3-D printing (3-DP) patent was filed by Charles Hull. Since then, substantial hype and growing demand has developed around a technology class that some anticipate will fundamentally change manufacturing across industries. Promising medical solutions such as bionic limbs, replacement organs, and advanced pharmaceutical ...

  • Project Number: EH0072-000

Dementia Villages

Last Updated: October 24, 2018
Result type: Reports

As the population ages, decision-makers are faced with different choices of care models for people diagnosed with dementia. Recent media reports have focused on dementia villages, first developed at de Hogeweyk in the Netherlands. This Horizon Scanning bulletin will present a narrative review of the literature describing elements of care, as wel...

  • Project Number: EH0071-000

An Overview of Clinical Applications of Artificial Intelligence

Last Updated: October 1, 2018
Result type: Reports
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Like many industries, health care is generating increased volumes of data and becoming increasingly reliant on it. Applications that use artificial intelligence (AI) may offer opportunities to make better use of health care’s increasingly data-driven environment and could change the way health care is delivered to Canadians.

  • Project Number: EH0070-000

Monoclonal Antibodies for Osteoarthritis of the Hip or Knee

Last Updated: July 11, 2018
Result type: Reports
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Osteoarthritis (OA) is a common and chronic disease of the synovial joints caused by biomechanical factors, inflammation, and joint tissue damage. The current therapeutic options include non-pharmacologic therapy and topical analgesics, followed by oral analgesics and injectable agents, followed by surgery for end-stage disease. OA typically ...

  • Project Number: EH0069-000

New Technologies for the Treatment of Peripheral Artery Disease

Last Updated: April 23, 2018
Result type: Reports
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Peripheral artery disease (PAD) is primarily caused by plaque in the arteries that supply blood to the body. It generally indicates systemic atherosclerosis and an increased risk for cardiovascular events. People with diabetes, those who smoke, the elderly, and those with cardiovascular disease are particularly at risk for PAD.

  • Project Number: EH0064-000

A Gene Expression Test to Assess the Likelihood of Obstructive Coronary Artery Disease

Last Updated: March 14, 2018
Result type: Reports
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Coronary artery disease is the most common form of cardiovascular disease in Canada. A new blood test, Corus CAD, combines age, sex, and gene expression in an algorithm to determine the likelihood a person has obstructive coronary artery disease. Corus CAD is intended for use in patients with suspected undiagnosed obstructive coronary artery ...

  • Project Number: EH0061-000

Voretigene Neparvovec: An Emerging Gene Therapy for the Treatment of Inherited Blindness

Last Updated: March 14, 2018
Result type: Reports
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Inherited retinal dystrophies (IRDs) are a major cause of early-onset blindness. Biallelic RPE65-mediated IRD, the most severe form of IRD, occurs when there are mutations in both alleles of the RPE65 gene in retinal pigment epithelium (RPE) cells. Voretigene neparvovec, developed by Spark Therapeutics, Inc., Pennsylvania, US, is a g...

  • Project Number: EH0067-000