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CADTH Style Guide

Published on: January 19, 2017
Result type: Reports
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Foreword Every industry is guided by standards, and the profession of editing is no exception. The Publishing Services team tries to stay on top of trends in the publishing industry, and the CADTH Style Guide is an example of that goal. This fifth edition of the CADTH Style Guide provides the most current style and language usage conventions for...

Interventions for Children with Cerebral Palsy: Guidelines

Published on: January 18, 2017
Result type: Reports
Product Line: Rapid Response
Research Type: Other Diagnostics

Key Messages

No evidence-based guidelines were identified regarding interventions for children with cerebral palsy.

  • Project Number: RA0884-000

Tags

Nervous System, Pediatrics, Cerebral Palsy, Nervous system, Pediatrics, spastic, diplegia, diplegias, cerebral palsies, Little disease, Little's disease

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    Short and Long Duration Residential Treatment Programs for Patients with Addiction: Comparative Clinical Effectiveness and Guidelines

    Published on: January 18, 2017
    Result type: Reports
    Product Line: Rapid Response
    Research Type: Devices and Systems

    Key Messages

    No relevant literature was found regarding short- versus long-term residential treatment programs for addiction.

    • Project Number: RB1052-000

    Tags

    Rehabilitation, Alcohol Drinking, Inpatients, Length of Stay, Residential Treatment, Substance Abuse Treatment Centers, Substance-Related Disorders, Therapeutic Community, Time Factors, Addiction, Rehabilitation, short term treatment, short-term treatment, long term treatment, long-term treatment, short duration, addictive disorder, addictive disorders, substance abuse, substance use, addictions, Alcoholic, Alcoholics, Alcoholism, alcohol abuse, length of treatment, treatment length, stay length, treatment period, treatment duration, recovery house, recovery home, recovery housing, treatment program, treatment programme, treatment programmes, inpatient treatment

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      Switching from Innovator to Biosimilar (Subsequent Entry) Infliximab: Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

      Published on: January 18, 2017
      Result type: Reports
      Product Line: Rapid Response
      Research Type: Drugs

      Key Messages

      Findings from observational studies on patients with rheumatoid arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s Disease, or ulcerative colitis suggest that switching from infliximab treatment to infliximab biosimilar may be possible without compromising efficacy or safety. However the findings need to be interpreted with caution as for most conditions the findings were from single studies, some of which were small in size. No relevant studies on patients with psoriatic arthritis were identified.   Two budget impact studies and a systematic review highlight potential for cost savings after the introduction of biosimilars to the market. No evidence-based guidelines regarding switching from innovator infliximab to subsequent entry infliximab were identified.

      • Project Number: RC0836-000

      Tags

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        Non-Prone or Supine Positioning During Laparoscopic Surgery: Safety

        Published on: January 16, 2017
        Result type: Reports
        Product Line: Rapid Response
        Research Type: Devices and Systems

        Key Messages

        No literature was identified regarding the safety of operating room table positioning systems during laparoscopic surgery.

        • Project Number: RA0883-000

        Tags

        Anesthesia, General, Laparoscopy, Operating Tables, Patient Positioning, Prone Position, Supine Position, Surgery, non prone, Anesthesia, patient position, supine

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          New at CADTH — January 2017

          Published on: January 16, 2017
          Result type: Reports
          Product Line: New at CADTH

          CORPORATE NEWS There is still time to send in your nominations for the CADTH Recognition Awards. Nominate a leader in the health technology assessment field and submit by January 30, 2017. Mark your calendars and plan to attend the 2017 CADTH Symposium from April 23 to 25, 2017, in Ottawa, Ontario. This year’s theme is “Measuring Value in Theory...

          Recognition and Diagnosis of Sepsis in Adults: A Review of Evidence-Based Guidelines

          Published on: January 13, 2017
          Result type: Reports
          Product Line: Rapid Response
          Research Type: Other Diagnostics

          Key Messages

          Six evidence-based guidelines were identified for diagnostic tests or processes for the recognition and detection of sepsis in adult populations. Three of these guidelines explored the recognition and detection of sepsis in broader populations, while three others focused on sepsis in cancer patients, sepsis in pregnancy and sepsis following pregnancy.Overall, areas of agreement across the guidelines included a variety of tests for the detecting sepsis, such as: temperature, heart rate, respiratory rate, blood pressure, level of consciousness, oxygen saturation, blood cultures; urine, cerebrospinal fluid, wounds, respiratory secretions, or other body fluids that may be the source of infection; lactate; urea; electrolytes; C-reactive protein; full blood count; kidney and liver function tests (including albumin). Finally, the guidelines consistently noted that imaging studies be complete to confirm a potential source of infection, with the exception of the NICE guideline for Neutropenic Sepsis in Cancer Patients, which stated Do not perform a chest X-ray unless clinically indicated.

          • Project Number: RC0841-000

          Tags

          Infection Control, Diagnosis, Sepsis, Systemic Inflammatory Response Syndrome, Infection control, Septicemia, Septicemic, Screening, Diagnostic, Assessment, assessing, diagnostic test, diagnostic tests, flowchart, flow chart

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            Basal-Bolus Versus Sliding-Scale Insulin Therapy in the Acute Care Hospital Setting: A Review of Comparative Clinical Effectiveness and Cost-Effectiveness

            Published on: January 12, 2017
            Result type: Reports
            Product Line: Rapid Response
            Research Type: Drugs

            Key Messages

            One systematic review and three primary studies on comparative clinical effectiveness in patients with type 1 or type 2 diabetes or newly-diagnosed or recurrent hyperglycemia were found. Patients receiving basal-bolus or basal-corrective insulin therapy had lower blood glucose levels and a lower risk of hyperglycemia than those receiving sliding-scale insulin therapy. No significant differences were found in the risk of adverse events between the two interventions. Results on lengths of hospitalization and the risk of hypoglycemia were mixed across the studies. No economic evaluations fulfilling the selection criteria were found.

            • Project Number: RC0840-000

            Tags

            Hospitalization, Inpatients, Insulins, Diabetes, insulin glargine, Lantus, Levemir, Insulin detemir, Long acting

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              Medical Marijuana for Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness and Guidelines

              Published on: January 11, 2017
              Result type: Reports
              Product Line: Rapid Response
              Research Type: Drugs

              Key Messages

              Based on one systematic review (SR) which included six studies in adults with PTSD, there is evidence from very low-quality studies to support the efficacy of smoked marijuana, oral THC, and nabilone in reducing some symptoms of PTSD. Side effects, described as mild to moderate were reported for only one retrospective chart review, in which nabilone was discontinued in 28% of patients. There were no guidelines identified regarding the use of medical marijuana or cannabinoids in PTSD.

              • Project Number: RC0838-000

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