Report in Brief
- What is the clinical effectiveness of negative pressure wound therapy for the treatment of diabetic foot ulcers?
- What is the cost-effectiveness of negative pressure wound therapy for the treatment of diabetic foot ulcers?
- What are the evidence-based guidelines for the use of negative pressure wound therapy for the treatment of diabetic foot ulcers?
The evidence presented in this report supports greater clinical efficacy of negative pressure wound therapy over other conventional treatments of diabetic foot ulcers. Conclusions are associated with a degree of uncertainty due to small sample sizes and potential for bias in the trials on which the evidence is based. There was no evidence identified suggesting an increased frequency of adverse events associated with negative pressure wound therapy. The majority of analyses also suggest that negative pressure wound therapy is more cost-effective than appropriate comparators, however the evidence also suggests this may not be the case in every healthcare setting and that improvements in efficacy estimates are needed to improve the accuracy of cost-effectiveness analysis. Identified guidelines suggest considering negative pressure wound therapy for diabetic foot ulcers, although the most recent Canadian guidelines identified cite a lack of evidence to support any recommendations regarding the use of negative pressure wound therapy.
vacuum-assisted closure, diabetic foot, negative-pressure wound therapy, wounds and injuries, diabetes, NPWT