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Cite as: Marshall J, Blackhouse G, Goeree R, Brazier N, Irvine E, Faulkner L, Dipchand C, O'Brien B. Infliximab for the Treatment of Crohn's Disease: A Systematic Review and Cost-Utility Analysis. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 2002. Technology report no 24. The Issue Crohn's disease (CD) is a c...
Cite as: Otten N. Economic evaluation of erythropoietin use in surgery. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1998. The Issue The use of allogeneic (donor) blood transfusion is associated with risks such as the transmission of infectious diseases including HIV and Hepatitis B and C. The perioperativ...
Technology Name Rosiglitazone (Avandia™) Pioglitazone (Actos™) Disease/Condition Diabetes mellitus is a serious disease characterized by an increase in blood glucose. It is estimated that more than one million Canadians over 12 years of age suffer from this condition. Type 2 diabetes is the most common form and affects 90% of persons with di...
Technology Name The novel antipsychotic drugs olanzapine (Zyprexa®) and risperidone (Risperdal®) Disease/Condition Dementia involves progressive loss of intellectual abilities such as language, comprehension, memory and learning, as well as changes in behaviour. This report focuses on agitation (restless movement with feelings of tension and ...
Technology Name Genetic tests for hereditary cancer predisposing syndromes Disease/Condition Individuals with hereditary cancer predisposing syndromes are at an increased risk of developing cancer. These syndromes can be diagnosed clinically, but in many instances, genetic tests must be conducted to make or refine the diagnosis. Technology D...
Technology Name Spinal manipulation for infant colic Disease/Condition Colic in infants is characterized by excessive and inconsolable crying that appears between the second and sixth weeks of life. Despite being a common occurrence, colic remains a medical enigma. The causes are unknown and despite significant research, a “cure” has not been...
Technology Name Interferon (IFN)-based antiviral therapies: standard IFN plus ribavirin versus standard IFN therapy alone standard IFN plus ribavirin versus pegylated IFN plus ribavirin Disease/Condition Chronic hepatitis C virus (HCV) infection Technology Description IFNs are human proteins that inhibit virus replication in infected c...
Technology Name Glycoprotein IIb/IIIa inhibitor drugs (abciximab and eptifibatide) Disease or Condition Blood clots (thrombi) and atherosclerotic plaque can block the coronary artery supplying blood to the heart. Blockage may result in heart pain (angina) or acute coronary syndrome, including unstable angina and myocardial infarction. Percuta...
Technology Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Disease This report explores 13 conditions for which the use of CT and MRI remain controversial: arteriovenous malformations carotid artery disease, cerebral aneurysms, coronary artery disease, headaches, head injuries, lung cancer screening, peripheral vascular disease...
Context and Policy Issues In the emergency department (ED), prompt and accurate diagnoses made by physicians are a prerequisite for the effective and timely treatment of patients with serious illnesses and injuries. Modern diagnostic methods such as ultrasonography (U/S) and computed tomographic (CT) scanning play a role in enhancing the qualit...