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Intravenous Immunoglobulin for Treatment of Idiopathic Thrombocytopenic Purpura: Economic and Health Service Impact Analyses

Published on: September 17, 2008
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology Intravenous immunoglobulin (IVIg), a blood product containing pooled IgG immunoglobulins derived from human plasma. Condition Idiopathic thrombocytopenic purpura (ITP) caused by an abnormal immune response that leads to low platelet counts and bleeding. Issue Because of the growing use of IVIg in Canada (including off-label use), esca...

Tags

Blood, Bruise, Plasma, Platelet Count, Skin, Treatment, Idiopathic Thrombocytopenic Purpura, Intravenous Immunoglobulins, Blood

Octreotide for Endocrine, Oncologic, and Gastrointestinal Disorders: Systematic Review and Budget Impact Analysis

Published on: July 21, 2008
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technologies Octreotide, which is a synthetic analogue of somatostatin, inhibits endocrine and exocrine secretions. Condition Octreotide is approved by Health Canada for use in acromegaly, neuroendocrine tumours, pancreatic surgery, and emergency bleeding of gastroesophageal varices. Octreotide is also being used for other unapproved indications...

Tags

Octreotide, Sandostatin, Gastric Varix, Esophageal Varix, Pancreatectomy, Intestinal Obstruction, Carcinoma, Hepatoma, Pancreas Cancer, Pancreatic Neoplasms, Hyperinsulinism, Acromegaly, Diarrhea, Endocrine Glands, Esophageal and Gastric Varices, Exocrine Glands, Gastrointestinal Disorders, Functional, Carcinoma, Hepatocellular, Hepatocellular Carcinoma, Pancreatic Cancer, Short Bowel Syndrome, Somatostatin, Neuroendocrine Tumors, Surgery, Sandostatin LAR, Octreotide Acetate Omega, OCT-LA, OCT-SA, Endocrine, Oncologic, Oncology, Gastrointestinal, Acromegaly Acromégalie, Somatotropin hypersecretion syndrome, GH hypersecretion, Growth hormone hypersecretion, Esophageal and Gastric Varices Varices oesophagiennes et gastriques Esophageal and Gastric Varices, Neuroendocrine Tumors Tumeurs neuroendocrines GEPNET, Gastroenteropancreatic neuroendocrine tumours, Gastroenteropancreatic neuroendocrine tumors, Pancreatectomy Pancréatectomie Pancreatic surgery, Intestinal Obstruction Occlusion intestinale Bowel obstruction, Diarrhea Diarrhée diarrhea, Hepatocellular Carcinome hépatocellulaire Hepatocellular Carcinoma, Hepatomas, Hepatocellular neoplasms, Pancreatic Neoplasms Tumeurs du pancréas Pancreatic cancer, Hyperinsulinism Hyperinsulinisme Pediatric idiopathic hyperinsulinism, Pediatric persistent hyperinsulinism, Short Bowel Syndrome Syndrome de l'intestin court Short bowel syndrome

Short-Acting Agents for Procedural Sedation and Analgesia in Canadian Emergency Departments: A Review of Clinical Outcomes and Economic Evaluation

Published on: March 31, 2008
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology Short-acting agents for procedural sedation and analgesia (PSAs) propofol, ketamine HCl, etomidate, and ketamine combined with low-dose propofol (ketofol). Condition Adults who present to emergency departments (EDs) for painful procedures (i.e., treatment for bone fractures, major joint dislocations, cardioversion, and other procedure...

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Analgesia, Opioids, Canada, Emergency Care, Sedatives, Anesthesia, Short-Acting Agents for Procedural Sedation and Analgesia in Canadian Emergency Departments, A Review of Clinical Outcomes and Economic Evaluation

Erythropoiesis-Stimulating Agents for Anemia of Chronic Kidney Disease: Systematic Review and Economic Evaluation

Published on: March 11, 2008
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology Erythropoiesis-stimulating agents (ESA), epoetin alpha (Eprex ®, Janssen-Ortho), darbepoetin (Aranesp ™, Amgen), and epoetin beta (NeoRecormon ®, Roche) Condition Adult patients with anemia of chronic kidney disease (CKD) who need or do not need dialysis. Issue ESAs are routinely used to treat anemia of chronic kidney disease (CKD), e...

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Erythropoietin, Chronic Kidney Failure, ESRD, Renal Failure, Economics, Anemia, Erythropoiesis Stimulating Agents, Kidney Failure, Chronic, Kidney/urologic, Recombinant Érythropoïétine recombinée Erythropoiesis-Stimulating Agents, ESA, darbepoetin, darbepoetin alfa, darbepoetin alpha, Aranesp, epoetin beta NeoRecormon, epoetin alpha, epoetin alfa, Eprex, Anemia Anémie Anemia, Anaemia, Anemic, Chronic Défaillance rénale chronique Chronic Kidney Disease, Chronic renal disease, Chronic renal failure, CKD, CRF, End stage kidney disease, End stage renal disease, Review Literature Revue de la littérature Systematic review, Clinical review, Economics Économie Economic evaluation, Economic analysis

Minimally Invasive Arthroplasty in the Management of Hip Arthritic Disease: Systematic Review and Economic Evaluation

Published on: February 12, 2008
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology Minimally invasive total hip replacement (MI THR) procedures that involve single- and double- incision techniques. Condition Patients who are eligible for THR due to degenerative, rheumatoid, or other arthritic diseases of the hip. Issue Emerging minimally invasive surgical techniques for hip replacement require specialized equipment....

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Arthroplasty, Hip, Minimally Invasive Surgical Procedures, Arthroplasty, Hip Replacement, Musculoskeletal, Minimally Invasive Arthroplasty in the Management of Hip Arthritic Disease, Systematic Review and Economic Evaluation

Recombinant human growth hormone for Turner syndrome: systematic review and economic evaluation

Published on: December 21, 2007
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology and Condition Recombinant human growth hormone (rhGH) for treatment of Turner syndrome (TS). Issue Given the high cost of rhGH treatment and the evolving evidence base for its clinical effect in patients with TS, policy makers need evidence
to inform reimbursement decisions about rhGH. Methods and Results A systematic review was...

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Growth Hormone, Somatropin, Humatrope, Serostim, Saizen, Nutropin, Economics, Genetics, Recombinant Growth Hormone, Turner Syndrome, Human Growth Hormone, Genetics, Recombinant human growth hormone for Turner syndrome, systematic review and economic evaluation Turner Syndrome Syndrome de Turner Turner syndrome, Turner’s syndrome, Turners syndrome, Human Growth Hormone Hormone de croissance humaine Recombinant human growth hormone, rhGH, Review Literature Revue de la littérature Systematic review, Clinical review, Economics Économie Economic evaluation, Economic analysis, Revue de la littérature, Systematic review, Clinical review, Économie, Economic evaluation, Economic analysis

Adalimumab, Alefacept, Efalizumab, Etanercept, and Infliximab for Severe Psoriasis Vulgaris in Adults: Budget Impact Analysis and Review of Comparative Clinical- and Cost-Effectiveness

Published on: December 21, 2007
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports
Research Type: Drug

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Dermatology, Psoriasis, Skin Abnormalities, Skin Diseases, Dermatology, Adalimumab, Alefacept, Efalizumab, Etanercept, and Infliximab for Severe Psoriasis Vulgaris in Adults, Budget Impact Analysis and Review of Comparative Clinical- and Cost-Effectiveness, ***, ***,

Thiazide Diuretics as First-Line Treatment for Hypertension: Meta-analysis and Economic Evaluation

Published on: December 21, 2007
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports

Technology and Condition Thiazide diuretics (TZD) chlorthalidone, hydrochlorothiazide, indapamide, and metolazone for primary hypertension (at least 140 mm Hg systolic or 90 mm Hg diastolic blood pressure). Issue Despite their demonstrated clinical effectiveness and low cost, the rate of first-line TZD use in newly treated hypertensive patients ...

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Sodium Chloride Cotransporter Inhibitors, Thiazide Sensitive NaCl Cotransporter Inhibitors, Thiazide Diuretics, Potassium Depleting Diuretics, Benzothiadiazine Diuretics, Review Literature, Review, Cost-Benefit Analysis, Hypertension, Meta-Analysis, Sodium Chloride Symporter Inhibitors, Hypertension, Sodium Chloride Symporter Inhibitors Inhibiteurs du symport chlorure sodium Sodium chloride symporter inhibitors, Thiazide diuretic, Thiazide-like diuretics, Thiazide-like diuretic, Postassium depleting diuretic, Benzothiadiazine diuretic, Hypertension Hypertension artérielle Hypertension, High blood pressure, High blood pressures, Revue de la littérature, systematic review, Meta-Analysis Méta-analyse descriptive overview, Cost-Benefit Analysis Analyse coût-bénéfice Cost-effectiveness, Inhibiteurs du symport chlorure sodium, Hypertension artérielle, Méta-analyse, descriptive overview, Analyse coût-bénéfice, Cost-effectiveness

Diagnostic Performance and Cost-Effectiveness of Technologies to Measure Bone Mineral Density in Postmenopausal Women

Published on: December 4, 2007
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports
Research Type: Devices and Systems

Context and policy issues Osteoporosis is a progressive disease characterized by low bone mass, microarchitectural bone tissue deterioration and loss of bone strength that can lead to an increased risk of fracture. The World Health Organization’s (WHO) definition of osteoporosis is a T score of ≤−2.5, which is equivalent to a hip bone mineral de...

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Osteoporosis, Bone Mineral Density, Postmenopausal Bone Loss, Postmenopause, Musculoskeletal, Diagnostic Performance and Cost-Effectiveness of Technologies to Measure Bone Mineral Density in Postmenopausal Women Osteoporosis low bone mass microarchitectural BMD

Effectiveness of magnetic resonance imaging (MRI) screening for women at high risk of breast cancer

Published on: October 31, 2007
Result type: Reports
Product Line: Health Technology Assessment, Technology Reports
Research Type: Devices and Systems

Context and Policy Issues In 2007, there will be an estimated 22,300 Canadian women diagnosed with breast cancer, and approximately 5,300 deaths. The risk factors for breast cancer include reproductive and hormonal factors, lifestyle factors, a family history of breast cancer, and mutation in the tumour suppression genes BRCA1 or BRCA2. Women at...

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Breast Neoplasms, Magnetic Resonance Imaging, Breast Cancer, Screening, MRI, Breast cancer, Keywords, high risk