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Triple csDMARDs for Rheumatoid Arthritis

Published on: December 12, 2018
Result type: Reports
Product Line: Optimal Use

Monotherapy conventional synthetic DMARD (csDMARDs; methotrexate preferred) is the drug of choice for treatment-naive patients with early or established rheumatoid arthritis for any level of disease activity according to the American College of Rheumatology 2015 Guidelines. When monotherapy with a csDMARD has been ineffective or partially effect...

  • Project Number: OP0543

Interventions for Insomnia Disorder

Published on: December 10, 2018
Result type: Reports
Product Line: Optimal Use

Insomnia is a sleep disorder affecting approximately 13% of the Canadian population. People with insomnia often have difficulty falling asleep or difficulty remaining asleep. They may also wake up frequently, experience early awakening, have a limited amount of sleep, or have a poor quality of sleep. Insomnia may be acute, meaning it generall...

  • Project Number: HT0003-OP0527

Optimal Use of Minimally Invasive Glaucoma Surgery: A Health Technology Assessment

Published on: December 3, 2018
Result type: Reports
Product Line: Optimal Use

Glaucoma is a leading cause of blindness. A range of surgical interventions exist for treating glaucoma, including a group of procedures commonly called micro-invasive or minimally invasive glaucoma surgery (MIGS). It has been noted that, across Canada, there is a growing demand for MIGS, as well as a rise in the use of MIGS procedures. At the s...

  • Project Number: OP0532-000

Tags

Eye, Filtering Surgery, Glaucoma, Glaucoma Drainage Implants, Microsurgery, Minimally Invasive Surgical Procedures, Ophthalmologic Surgical Procedures, Ophthalmology, Sclerostomy, Stents, Trabeculectomy, Medical devices, Surgery, Antiglaucoma, MIGS, Minimally Invasive, OAG, POAG, Stent, eyes, micro, ocular, shunt, shunts

Axicabtagene Ciloleucel for Adults With Relapsed or Refractory Large B-cell Lymphoma

Published on: October 25, 2018
Result type: Reports
Product Line: Optimal Use

Axicabtagene ciloleucel is a chimeric antigen receptor (CAR) T-cell therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma. This includes diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma, and sub-types of DLBCL (e.g., primary mediastinal large B-cell lymphoma and DLBCL arising from follicul...

  • Project Number: CT0002-000

Tags

Antigen, Antigens, Cancer, Genetics, Lymphoma, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Cancer, Cancer, Genetics, Lymphoma, CAR-T, CAR-T cells, CD19, CTL 019, CTL019, DLBCL, Diffuse, Large B-Cell, Receptors, T-Cell, chimeric antigen receptor

Tisagenlecleucel (Kymriah) for Pediatric Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma

Published on: September 21, 2018
Result type: Reports
Product Line: Optimal Use

Tisagenlecleucel is a chimeric antigen receptor (CAR) T-cell therapy for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) and children and adolescents with relapsed or refractory acute lymphoblastic leukemia (R/R ALL). CADTH is undertaking an Optimal Use project to assess the clinical impact, cost-eff...

  • Project Number: OP0538-000

Tags

Antigen, Antigens, Cancer, Genetics, Leukemia, Lymphoma, Pediatrics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Cancer, Cancer, Genetics, Lymphoma, Pediatrics, Acute lymphoblastic leukemia, CAR-T, CAR-T cells, CD19, CTL 019, CTL019, DLBCL, Diffuse, Kymriah, Large B-Cell, Receptors, T-Cell, all, chimeric antigen receptor

Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration

Published on: September 12, 2018
Result type: Reports
Product Line: Optimal Use

This project will assess the clinical and economic effectiveness of extending dual antiplatelet therapy (i.e., the combination of ASA and a P2Y12 inhibitor) following percutaneous coronary intervention; findings will be summarized in a Science Report. This report will aim to answer the following policy questions: Is it cost-effective to extend t...

  • Project Number: OP0533-000

Tags

Angioplasty, Aspirin, Platelet Aggregation Inhibitors, Purinergic P2Y Receptor Antagonists, Stents, Cardiovascular, Surgery, Balloon, Brilinta, Brilique, DAPT, DES, Effient, Laser-Assisted, PCI, Percutaneous Coronary Intervention, Plavix, Stent, Stenting, angioplasties, prasugrel, ticagrelor

Internet-delivered, cognitive behavioural therapy for major depressive disorder and anxiety disorders : Patients’ Perspectives and Experiences, Ethics, and Implementation Issues

Published on: July 9, 2018
Result type: Reports
Product Line: Optimal Use
Research Type: Device

Major depressive disorder (MDD) is the occurrence of one or more major depressive episodes that last at least two weeks. Anxiety disorders include a range of conditions, including generalized anxiety disorder, panic disorder, and social anxiety disorder. The treatment of MDD and anxiety disorders can include pharmacological and/or psychological ...

  • Project Number: OP0534-000

Tags

Anxiety Disorders, Depression, Mental Health, Anxiety disorders, Depression, Dépression, Mental health

csDMARDs for Rheumatoid Arthritis

Published on: May 25, 2018
Result type: Reports
Product Line: Optimal Use

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease characterized by inflammation of the synovial lining of the joints, tendons and periarticular structures. Definitive treatments that have disease-modifying potential include glucocorticoids, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs, such as metho...

  • Project Number: OP0539-000

HPV Testing for Primary Cervical Cancer Screening

Published on: April 17, 2018
Result type: Reports
Product Line: Optimal Use

The majority of sexually active women will acquire a human papillomavirus (HPV) infection in their lifetime, and an estimated 10% of these infections can develop into cervical cancer. Women in all Canadian jurisdictions have access to cervical cancer screening using the cytology-based Papanicolaou (Pap) test. While implementation of the Pap t...

  • Project Number: OP0530-000

Tags

Cancer, Cervical Intraepithelial Neoplasia, DNA Probes, Early Detection of Cancer, Mass Screening, Papillomavirus Infections, Screening, Triage, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Vaginal Smears, Cancer, Cancer, Gynecology/obstetrics, Laboratory tests, HPV, HPV infection, HPV infections, HPV test, HPV testing, HPV tests, Human Papillomavirus DNA Tests, Human Papillomavirus testing, Human Papillomavirus tests, cervical cancer, cervical neoplasm, human papillomavirus test

Dialysis Modalities for the Treatment of End-Stage Kidney Disease

Published on: March 23, 2018
Result type: Reports
Product Line: Optimal Use

CADTH undertook a health technology assessment (HTA) to inform decision-making about the appropriate use of dialysis modalities for the treatment of end-stage kidney disease (ESKD). The HTA addressed the clinical effectiveness, cost-effectiveness, patient experiences and perspectives, ethical issues, and implementation issues of dialysis modali...

  • Project Number: OP0526-000

Tags

Chronic Kidney Failure, Dialysis, Hemodialysis, Home Hemodialysis, Kidney, Peritoneal Dialysis, Medical devices, Chronic Kidney Disease, Haemodialysis, Hemodialyses, Homecare, assisted peritoneal dialysis, end stage kidney disease, end stage renal disease, home dialysis, home haemodialysis, long term care, longterm care, self care dialysis, self care haemodialysis, self care hemodialysis, self dialysis, shared dialysis, shared haemodialysis, shared hemodialysis