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HPV Testing for Primary Cervical Cancer Screening

Last Updated: April 10, 2019
Result type: Reports
Product Line: Optimal Use

Worldwide, cervical cancer is one of the most frequently diagnosed cancers; however, the incidence of cervical cancer has been decreasing in the past three decades, largely due to routine screening with cytology. HPV is the major risk factor for the development of cervical cancer, with 99% of cervical cancer being associated with HPV. It is one ...

  • Project Number: OP0530-000

Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration

Last Updated: April 4, 2019
Result type: Reports
Product Line: Optimal Use

This project evaluated the clinical and economic effectiveness of extending dual antiplatelet therapy, or DAPT (i.e., a combination of ASA and a P2Y12 inhibitor), following percutaneous coronary intervention (PCI). This project aimed to answer the following policy questions: Policy Question 1: Should P2Y12 inhibitors (i.e., clopidogrel, prasugre...

  • Project Number: OP0533-000

Internet-Delivered Cognitive Behavioural Therapy for Major Depressive Disorder and Anxiety Disorders: A Health Technology Assessment

Last Updated: March 19, 2019
Result type: Reports
Product Line: Optimal Use
Research Type: Device

Major depressive disorder (MDD) is the occurrence of one or more major depressive episodes that last at least two weeks. Anxiety disorders include a range of conditions, including generalized anxiety disorder, panic disorder, and social anxiety disorder. MDD and anxiety disorders may be treated with pharmacological and/or psychological intervent...

  • Project Number: OP0534-000

Optimal Use of Minimally Invasive Glaucoma Surgery: A Health Technology Assessment

Last Updated: March 14, 2019
Result type: Reports
Product Line: Optimal Use

Glaucoma is a leading cause of blindness. A range of surgical interventions exist for treating glaucoma, including a group of procedures commonly called micro-invasive or minimally invasive glaucoma surgery (MIGS). It has been noted that, across Canada, there is a growing demand for MIGS, as well as a rise in the use of MIGS procedures. At the s...

  • Project Number: OP0532-000

Internet-Based Cognitive Behavioural Therapy for Post-Traumatic Stress Disorder

Last Updated: March 6, 2019
Result type: Reports
Product Line: Optimal Use

Post-Traumatic Stress Disorder (PTSD) occurs as a response to an acute traumatic event or an extreme stressor. Symptoms include fear, helplessness, hyperarousal, re-experiencing of the event, and avoidance of reminders of the event for at least one month. PTSD can be treated with pharmacological and psychological interventions such as cognitive ...

  • Project Number: OP0537-000

Tisagenlecleucel (Kymriah) for Pediatric Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma

Last Updated: January 15, 2019
Result type: Reports
Product Line: Optimal Use

Tisagenlecleucel is a chimeric antigen receptor (CAR) T-cell therapy for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma and children and young adults with relapsed or refractory acute lymphoblastic leukemia. CADTH undertook a review of manufacturer-submitted materials and published literature to assess the clin...

  • Project Number: OP0538-000 / CT0001

Triple csDMARDs for Rheumatoid Arthritis

Last Updated: December 12, 2018
Result type: Reports
Product Line: Optimal Use

Monotherapy conventional synthetic DMARD (csDMARDs; methotrexate preferred) is the drug of choice for treatment-naive patients with early or established rheumatoid arthritis for any level of disease activity according to the American College of Rheumatology 2015 Guidelines. When monotherapy with a csDMARD has been ineffective or partially effect...

  • Project Number: OP0543-000

Interventions for Insomnia Disorder

Last Updated: December 10, 2018
Result type: Reports
Product Line: Optimal Use

Insomnia is a sleep disorder affecting approximately 13% of the Canadian population. People with insomnia often have difficulty falling asleep or difficulty remaining asleep. They may also wake up frequently, experience early awakening, have a limited amount of sleep, or have a poor quality of sleep. Insomnia may be acute, meaning it generall...

  • Project Number: HT0003-OP0527

csDMARDs for Rheumatoid Arthritis

Last Updated: October 30, 2018
Result type: Reports
Product Line: Optimal Use

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease characterized by inflammation of the synovial lining of the joints, tendons and periarticular structures. Definitive treatments that have disease-modifying potential include glucocorticoids, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs, such as metho...

  • Project Number: OP0539-000

Axicabtagene Ciloleucel for Adults With Relapsed or Refractory Large B-cell Lymphoma

Last Updated: October 25, 2018
Result type: Reports
Product Line: Optimal Use

Axicabtagene ciloleucel is a chimeric antigen receptor (CAR) T-cell therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma. This includes diffuse large B-cell lymphoma (DLBCL), high grade B-cell lymphoma, and sub-types of DLBCL (e.g., primary mediastinal large B-cell lymphoma and DLBCL arising from follicul...

  • Project Number: CT0002-000