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Optical Scanners for Melanoma Detection

Last Updated: March 31, 2014
Result type: Reports

The key to a melanoma cure is early detection before the cancer has spread beyond the epidermal skin layer. Several novel, hand-held, automated optical scanning devices have been developed to aid care providers in early diagnosis. These technologies quickly and non-invasively permit visualization deeper into the skin to detect evidence of mal...

  • Project Number: EH0008

Obstructive Sleep Apnea: A Palatable Treatment Option?

Last Updated: January 30, 2007
Result type: Reports

The Pillar® Palatal Implant System consists of three polyester threads that are permanently implanted in the palate (the roof of the mouth) to reduce airway obstruction in individuals with mild to moderate obstructive sleep apnea (OSA) and snoring. Three small, non-randomized uncontrolled trials reported a moderate reduction in the number of ...

  • Project Number: E0008

Percutaneous vertebroplasty: A bone cement procedure for spinal pain relief

Last Updated: June 7, 2002
Result type: Reports

Percutaneous vertebroplasty (PV), a procedure where bone cement is injected into a partially collapsed vertebral body, is used to relieve pain and provide mechanical stability in cases of osteoporosis or tumour infiltration. PV provided rapid pain relief and increased mobility in most patients according to the results from 15 uncontrolle...

Pegaptanib for Neovascular Age-related Macular Degeneration

Last Updated: December 8, 2005
Result type: Reports

Neovascular (wet) age-related macular degeneration (AMD) results from the  growth of abnormal blood vessels under the retina (choroidal neovascularization). Sudden and permanent vision loss occurs as these vessels grow, leak, bleed, and scar. A human protein, vascular endothelial  growth factor (VEGF), is implicated in the deve...

Omalizumab as add-on therapy to inhaled steroids for asthma

Last Updated: June 16, 2004
Result type: Reports

In the US, subcutaneous administration of omalizumab is indicated for adults and adolescents (age ≥12 years) with allergic asthma that is moderate to severe and inadequately controlled with inhaled corticosteroids. In placebo-controlled trials, omalizumab reduces asthma exacerbations and the need for inhaled steroids in this gr...

Afrezza Inhaled Insulin for Diabetes Mellitus

Last Updated: January 23, 2013
Result type: Reports

Afrezza is a drug-device combination consisting of Technosphere insulin (TI) inhalation powder and a product-specific breath-activated inhaler. TI cartridges are used with an inhaler one minute before eating for managing type 1 and type 2 diabetes. TI significantly reduces postprandial glucose and glycated hemoglobin (A1C) levels in type 2 di...

  • Project Number: EH0003

Nuchal Translucency Measurement in First Trimester Down Syndrome Screening

Last Updated: June 27, 2007
Result type: Reports

Approximately three in every four fetuses with Down syndrome have increased nuchal translucency (NT), which is a larger than normal build-up of fluid at the back of the neck. The ultrasound measurement of NT between 11 and 14 weeks' gestation, in combination with the mother's age and the levels of placental biochemical markers in her blood, c...

  • Project Number: E0021

Alefacept: Potential new therapy for patients with moderate-to-severe psoriasis.

Last Updated: April 4, 2003
Result type: Reports

Alefacept is a new biotechnology product designed for the treatment of patients with chronic plaque-type psoriasis who have disease severe enough to make them eligible for phototherapy or systemic therapy. In two randomized controlled phase III trials of patients with moderate-to-severe disease, alefacept showed a modest but statist...

Capsule Colonoscopy: PillCam® Colon

Last Updated: October 23, 2007
Result type: Reports

The PillCam® Colon capsule is an ingestible miniature camera that captures images of the colon's inner lining. There is limited evidence on the use of this technology in imaging the colon. Two small, methodologically flawed pilot studies found that for patients with positive findings (i.e., abnormalities detected), the rates of detection with...

  • Project Number: E0034