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Smoking Reduction and Cessation Interventions for Pregnant Women and Mothers of Infants: A Review of the Clinical Effectiveness

Last updated: July 4, 2017
Project Number: RC0900-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What is the clinical effectiveness of smoking reduction programs for pregnant women or mothers of infants?
  2. What is the clinical effectiveness of smoking cessation interventions for pregnant women or mothers of infants?

Key Message

Evidence on the effectiveness of smoking reduction interventions was limited. Psychosocial interventions for smoking cessation appeared to be effective, while the effect of health education and social support was less certain. The results suggested that psychosocial interventions reduced the risk of infants born with low birthweight, increased the mean birthweight, and decreased the risk of neonatal intensive care unit admission. Pharmacological interventions appeared to be effective during treatment or at the end of pregnancy. Nicotine replacement therapy did not seem to have any positive or negative effects on infant outcomes, while the safety of bupropion was inconclusive.