Findings from observational studies on patients with rheumatoid arthritis, ankylosing spondylitis, plaque psoriasis, Crohn’s Disease, or ulcerative colitis suggest that switching from infliximab treatment to infliximab biosimilar may be possible without compromising efficacy or safety. However the findings need to be interpreted with caution as for most conditions the findings were from single studies, some of which were small in size. No relevant studies on patients with psoriatic arthritis were identified. Two budget impact studies and a systematic review highlight potential for cost savings after the introduction of biosimilars to the market. No evidence-based guidelines regarding switching from innovator infliximab to subsequent entry infliximab were identified.