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Tamper-Resistant Oxycodone: A Review of the Clinical Evidence and Cost-effectiveness

Last updated: June 25, 2015
Project Number: RC0675-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical evidence on the harms associated with non-tamper-resistant oxycodone formulations in adults, including misuse and abuse?
  2. What is the clinical evidence on the harms associated with tamper-resistant oxycodone formulations in adults, including misuse and abuse?
  3. What is the evidence for the reduction of misuse, abuse, and related harms with tamper-resistant oxycodone compared with non-tamper resistant formulations?
  4. What is the cost-effectiveness of tamper-resistant oxycodone?
  5. What are the evidence-based guidelines for the use of tamper-resistant oxycodone?

Key Message

Evidence from RCTs and observational studies suggest that tamper-resistant oxycodone has the potential to reduce misuse, abuse and their associated harms. Tamper-resistant oxycodone formulations may also decrease healthcare costs associated with the misuse and abuse of oxycodone.