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Topical Skin Refrigerant Sprays to Support Pain Management during Minor Procedures: Clinical Effectiveness, Safety, and Guidelines

Last updated: August 29, 2011
Project Number: RB0410-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary of Abstracts
Result type: Report

Question

  1. What is the clinical effectiveness of topical skin refrigerant sprays that do not contain ethyl chloride to support pain management during minor outpatient procedures?
  2. What is the clinical evidence for the safety of topical skin refrigerant sprays to support pain management during minor outpatient procedures?
  3. What are the evidence-based guidelines regarding the use of topical skin refrigerant sprays to support pain management during minor outpatient procedures?

Key Message

Evidence suggests that non-ethyl chloride vapocoolant sprays are safe and effective for reducing pain during intravenous cannulation, but evidence is mixed regarding the effectiveness of these sprays for pain reduction during immunization.