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The Use of Medical Cannabis with Other Medications: A Review of Safety and Guidelines

Published on: April 19, 2017
Project Number: RC0878-000
Product Line: Rapid Response
Research Type: Drug
Report Type: Summary with Critical Appraisal
Result type: Report

Question

  1. What is the clinical evidence regarding the safety of the use of medical cannabis with other medications?
  2. What are the evidence-based guidelines regarding the interaction of the use of medical cannabis with other medications?

Key Message

Limited data on medical cannabis and drug-drug interactions were obtained from a low quality systematic review. Nabilone may have additive depressant effects with diazepam when taken together with alcohol and codeine, and it may decrease the need for opioids, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, dexamethasone and ondansetron when used concomitantly. No evidence-based guidelines were identified.

Tags

mental health, cannabinoids, cannabis, drug interactions, marijuana smoking, pharmaceutical preparations, receptors, cannabinoid, other miscellaneous topics, marijuana, complementary medicine, illicit substance, Alcohol, Therapeutic, marihuana