Video-Oculography for the Diagnosis of Ocular Myasthenia Gravis: A Review of Diagnostic Accuracy, Cost-Effectiveness, and Guidelines

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Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC1126-000

Question

  1. What is the comparative diagnostic accuracy of eye-movement analysis using video-oculography versus single fibre electromyography (EMG) for detection of ocular myasthenia gravis?
  2. What is the comparative cost-effectiveness of eye-movement analysis using video-oculography versus single fibre EMG for detection of ocular myasthenia gravis?
  3. What are the evidence based guidelines regarding the use of eye-movement analysis using video-oculography for suspected ocular myasthenia gravis?

Key Message

No relevant evidence regarding the comparative diagnostic accuracy or cost-effectiveness of video-oculography versus single fibre electromyography for the detection of ocular myasthenia gravis was identified. There were no evidence-based guidelines providing recommendations on the use of video-oculography for the detection of ocular myasthenia gravis. Further research on the use of video-oculography for the diagnosis of ocular myasthenia gravis, compared with current methods, such as electromyography, may help to reduce the uncertainty regarding its use in clinical practice.