Risk Factors and Preventive Interventions for Post‒COVID-19 condition


Project Status:
Project Line:
Health Technology Review
Project Sub Line:
Systematic Review
Project Number:

Post‒COVID-19 condition ― also referred to as long COVID or post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), among other names ― is a condition characterized by new or persisting symptoms beyond the acute phase of the disease (e.g., for more than 4 or 12 weeks following an initial COVID-19 infection, clinical definition pending). People with post‒COVID-19 condition may experience a range of heterogenous symptoms including fatigue, shortness of breath, muscle aches, and cognitive and mental health challenges.

CADTH contributed to a systematic review by The Alberta Research Centre for Health Evidence (ARCHE) and, the Public Health Agency of Canada (PHAC), that assessed the associations between pre-existing and clinical risk factors and the development of post COVID-19 condition, and the effects of interventions in the acute or early post-acute phase of COVID-19 to prevent post‒COVID-19 condition.

The project protocol can be found here.