Cabergoline or Quinagolide versus Bromocriptine for Hyperprolactinemia with or without Prolactinoma: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

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RA1068-000

Question

  1. What is the clinical effectiveness of cabergoline versus bromocriptine as a first-line medication therapy for patients with hyperprolactinemia with or without prolactinoma?
  2. What is the cost-effectiveness of cabergoline versus bromocriptine as a first-line medication therapy for patients with hyperprolactinemia with or without prolactinoma?
  3. What is the clinical effectiveness of quinagolide versus bromocriptine as a first-line medication therapy for patients with hyperprolactinemia with or without prolactinoma?
  4. What is the cost-effectiveness of quinagolide versus bromocriptine as a first-line medication therapy for patients with hyperprolactinemia with or without prolactinoma?
  5. What are the evidence-based guidelines regarding medication therapy for patients with hyperprolactinemia with or without prolactinoma?

Key Message

Four systematic reviews (three with meta-analyses), one randomized controlled trial, and five non-randomized studies were identified regarding the clinical effectiveness of cabergoline versus bromocriptine as a first-line medication therapy for patients with hyperprolactinemia with or without prolactinoma. One evidence-based guideline was identified regarding medication therapy for patients with hyperprolactinemia.