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Circulating Tumour DNA Testing for the Identification of Genetic Mutations: Diagnostic Test Accuracy and Clinical Utility

Last updated: February 24, 2020
Project Number: RA1081-000
Product Line: Rapid Response
Research Type: Other Diagnostics
Report Type: Reference List
Result type: Report

Question

  1. What is the diagnostic test accuracy of circulating tumour DNA testing for the identification of genetic mutations?
  2. What is the clinical utility of circulating tumour DNA testing for the identification of genetic mutations?
  3. What is the cost-effectiveness of circulating tumour DNA testing for the identification of genetic mutations?

Key Message

Four systematic reviews and meta-analyses, three randomized controlled trials, and 44 non-randomized studies were identified regarding the diagnostic test accuracy and clinical utility of circulating tumour DNA testing for the identification of genetic mutations.