e-Therapy Interventions for the Treatments of Patients with Depression: A Review of Clinical Effectiveness


Project Status:
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:


  1. What is the clinical effectiveness of e-therapy for the treatment of patients with depression?

Key Message

Evidence from a small number of systematic reviews (SRs) and small size randomized controlled trials (RCTs) consistently showed that therapist-guided e-therapy was superior to no treatment, wait list, or TAU in reducing depressive symptoms on patients with depression and major depressive disorder. Therapist-guided e-therapy was found to be equivalent to standard face-to-face CBT for patients with MDD, and the combination of e-therapy and TAU was equivalent to TAU alone in patients with depression.