What is the clinical effectiveness of endobronchial valves for people with severe emphysema?
This review identified one systematic review and two randomized controlled trials assessing the efficacy and safety of two types of endobronchial valves (i.e., Zephyr one-way EBV and Spiration Valve System) for bronchoscopic lung volume reduction in patients with severe emphysema. Endobronchial valve therapy with Zephyr EBV was associated with significantly greater lung function, exercise capacity, quality of life, and significantly reduced dyspnea for up to 12 months, with increased risk of serious adverse events, compared to standard medical care. Although Spiration Valve System-treated patients showed significantly greater lung function and quality of life in comparison to patients treated with standard medical care, further work is required to demonstrate with confidence the efficacy and safety of Spiration Valve System. Pneumothorax was the most reported complication during treatment with endobronchial valves.