Immune Checkpoint Inhibitors for Non–Small Cell Lung Cancer With Genomic Aberrations

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Project Status:

Active

Project Line:

Health Technology Review

Project Sub Line:

Systematic Review

Project Number:

RE0050-000

Immune checkpoint inhibitors (ICIs) are approved as monotherapy for non–small cell lung cancer (NSCLC). Metastatic NSCLC with mutations or rearrangements (ALK, EGFR, ROS-1, BRAF, MET, RET) are known to respond poorly to ICIs and should be first treated with targeted drugs and chemotherapy. This systematic review will synthesize the evidence on the benefits of ICIs when used as third-line therapy or beyond for mutated NSCLC.

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Proposed Protocol View PDF

Last Updated : February 1, 2024