New at CADTH — September 2018

News and Events

CADTH was pleased to have announced the appointment of Mr. David Agnew, President of Seneca College, to Chair of the CADTH Board of Directors.

Health Canada, CADTH, and INESSS are hosting a webinar September 26, 2018, from 10:00 AM to 12:00 PM EDT to provide details on the aligned review process that was announced in June 2018. The webinar is open to all CADTH staff. To participate, please send your name and email address to [email protected].

Save the date. The 2019 CADTH Symposium is being held in Edmonton, Alberta, from April 14 to 16, 2019. We’re looking forward to seeing you there.

Drug Reimbursement Recommendations

CADTH recently issued the following CADTH Canadian Drug Expert Committee (CDEC) drug reimbursement recommendations:

• dupilumab (Dupixent) for atopic dermatitis
• darunavir/cobicistat/emtricitabine/tenofovir alafenamide (Symtuza) for HIV-1 infection
• buprenorphine subdermal implant (Probuphine) for opioid dependence
• nitisinone (Nitisinone) for hereditary tyrosinemia type 1
• eluxadoline (Viberzi) for irritable bowel syndrome with diarrhea
• ixekizumab (Taltz) for active psoriatic arthritis
• levodopa / carbidopa (Duodopa) for Parkinson’s disease
• abobotulinumtoxinA (Dysport Therapeutic) for lower limb spasticity
• fluticasone furoate / umeclidinium / vilanterol (Trelegy Ellipta) for chronic obstructive pulmonary disease

CADTH recently issued the following pCODR Expert Review Committee (pERC) drug reimbursement recommendations:

• atezolizumab (Tecentriq) for non–small cell lung cancer
• alectinib (Alecensaro) for non–small cell lung cancer
• trifluridine and tipiracil (Lonsurf) for metastatic colorectal cancer 
• inotuzumab ozogamicin (Besponsa) for acute lymphoblastic leukemia

CADTH Reports

CADTH recently completed the following reports:

Rapid Response Reports — Drug

• Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness— Reference List
• Radioembolization with yttrium-90 Microspheres for the Management of Uveal Melanoma Liver Metastases: A Review of Clinical Effectiveness and Cost-Effectiveness— Summary with Critical Appraisal
• Rituximab for the Treatment of Myasthenia Gravis: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Rituximab Maintenance Therapy for the Management of Granulomatosis with Polyangiitis or Microscopic Polyangiitis: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Eltrombopag for the treatment of Aplastic Anemia: A Review of Clinical and Cost-Effectiveness — Summary with Critical Appraisal
• Oral Glucose Gel for Neonatal Hypoglycemia: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines — Summary with Critical Appraisal
• Rituximab Maintenance Therapy for the Management of Granulomatosis with Polyangiitis or Microscopic Polyangiitis: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Biologics Dose Escalation for the Treatment of Inflammatory Bowel Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal

Rapid Response Reports — Medical Devices and Systems

• Therapies for the Management of Suicidality: Clinical Effectiveness — Reference List
• Low Carbohydrate Diet in Pregnancy: Clinical Effectiveness and Guidelines — Reference List
• Treating and Assessing Chronic Pain Patients who have Suffered Physical Trauma: Clinical Evidence and Guidelines — Summary of Abstracts
• Systematic Approach for the Treatment of Patients: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Breast Implants: Comparative Clinical Effectiveness — Summary of Abstracts
• Rheumatoid Factor Testing: Guidelines— Summary of Abstracts
• Requests and Referrals for Allergy Testing: Guidelines — Summary of Abstracts
• Foot Care Interventions for Adults in the Community Setting: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Pre-operative Internal Medicine and Anesthesiology Consultations for Elective Surgeries: Clinical Effectiveness and Guidelines — Summary of Abstracts
• Gastrostomy versus Gastrojejunostomy and/or Jejunostomy Feeding Tubes: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines — Summary with Critical Appraisal
• Bowel Preparation for Elective Colorectal Procedures: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines — Summary with Critical Appraisal
• Decompression with Rectal Tubes in Long-term Care Residents Experiencing Intestinal Pseudo-Obstruction: Clinical Effectiveness, Safety, and Guidelines — Summary of Abstracts
• Wet Needling Techniques in Patient Care: Clinical Effectiveness and Guidelines — Summary of Abstracts

Rapid Response Reports — Non-Surgical Procedures

• Support Following Sexual Misconduct in the Workplace: Evidence Based Guidelines — Reference List

Rapid Response Reports — Other Diagnostics

• Cultural Safety for Health Care Providers Treating Indigenous Patients: Guidelines  — Summary of Abstracts
• Resilience Tools for Trauma Informed Care in Patients: Clinical Effectiveness — Summary of Abstracts
• Positron Emission Tomography–Computed Tomography for Neurological Indications: Diagnostic Accuracy, Clinical Utility, Cost-Effectiveness, and Guidelines — Summary of Abstracts
• Post-Partum Screening and Monitoring for Gestational Diabetes: Clinical Effectiveness and Guidelines — Summary of Abstracts

Horizon Scan Reports

• Monoclonal Antibodies for Osteoarthritis of the Hip or Knee
• The Health Technology Update — Issue 21 table of contents includes:
  • Intelligent Retinal Imaging Systems for the Telescreening of Diabetic Retinopathy
  • MELODY: A Teleoperated Robotic Ultrasound System
  • Video Directly Observed Therapy of Tuberculosis Treatment
  • A Rapid Point-of-Care Test to Differentiate Bacterial From Viral Acute Upper Respiratory Infections
  • Focus On: Drone Applications in Health Care
  • Mini-Roundup: Recent Horizon Scanning Reports from CADTH and Other Agencies

CADTH Tools and Resources

• CADTH’s free online resource for grey literature searching has been updated — Grey Matters: a practical tool for searching health-related grey literature.
• CADTH’s Opioid Evidence Bundle has been updated. This bundle includes our best evidence on opioids and covers the topics of pain treatment; misuse/abuse, overdose, and harms; opioid use disorder and addiction treatment; and alternatives to opioids.

Tell Us What You Think

We love hearing how our products and services are influencing health care policies, clinical practices, and patient outcomes. If you have a success story to share, please get in touch with your CADTH Liaison Officer.

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