Post-Exposure Antibiotic Chemoprophylaxis for the Prevention of Invasive Group A Streptococcal Disease

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Project Status:
Completed
Project Line:
Reference List
Project Sub Line:
Reference List
Project Number:
RA1207-000

Question

  1. What is the clinical effectiveness of post-exposure antibiotic chemoprophylaxis for the prevention of invasive group A streptococcal (iGAS) disease in close contacts of people with iGAS disease?
  2. What is the cost-effectiveness of post-exposure antibiotic chemoprophylaxis for the prevention of iGAS disease in close contacts of people with iGAS disease?
  3. What are the evidence-based guidelines regarding the use of post-exposure antibiotic chemoprophylaxis for the prevention of iGAS disease in close contacts of people with iGAS disease?

Key Message

No evidence was identified regarding the clinical effectiveness of post-exposure antibiotic chemoprophylaxis for the prevention of invasive group A streptococcal disease in close contacts of people with invasive group A streptococcal disease.

No evidence was identified regarding the cost-effectiveness of post-exposure antibiotic chemoprophylaxis for the prevention of invasive group A streptococcal disease in close contacts of people with invasive group A streptococcal disease.

Two evidence-based guidelines were identified regarding the use of post-exposure antibiotic chemoprophylaxis for the prevention of invasive group A streptococcal disease in close contacts of people with invasive group A streptococcal disease.