Risk of Sexual Transmission of HIV With Antiretroviral Therapy and Variable or Suppressed Viral Load


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Health Technology Review
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Technology Review
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The absolute risk of HIV transmission through sexual activity, reported as incidence rates of observed seroconversions across person-years of follow-up, ranged widely across the included studies of sex partners living with HIV with variable (or unreported) viral loads. 

Two studies included sex partners living with HIV with suppressed viral loads of fewer than 200 copies/mL, reporting no phylogenetically linked seroconversions in either study.

Most studies in this report included data from heterosexual serodiscordant sex partners and did not report follow-up viral loads of sex partners living with HIV.

The included studies incorporated variable methods, investigated a broad variety of populations and exposures, and demonstrated a wide range of methodological strengths and limitations.